Electroencephalographic and autonomic effects of centrally administered dermorphin in rabbits

A. Tartara, M. Maurelli, E. Marchioni

Research output: Contribution to journalArticle

Abstract

Dermorphin, administered into the third ventricle of conscious rabbits, induces an increase of the total power density spectrum of the cortex and a decrease of the total power of the hippocampus. The electrocortical pattern is similar to that found with other opiates and reported as specific of mu agonists. Simultaneously the peptide causes respiratory depression, bradycardia and hypothermia. Naloxone (0.5 mg/kg IV) quckly and completely inverts all these effects. The activity of serotoninergic, Gabaergic, catecholaminergic and cholinergic systems does not seem to be required for these dermorphin actions. Thus, the hypothesis that dermorphin acts directly in modifying cerebral electrical activity is put forward.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalPeptides
Volume6
Issue numberSUPPL. 3
DOIs
Publication statusPublished - 1985

Fingerprint

Autonomic Agents
Rabbits
Opiate Alkaloids
Hypothermia
Third Ventricle
Bradycardia
Naloxone
Respiratory Insufficiency
Cholinergic Agents
Hippocampus
Peptides
dermorphin

Keywords

  • Autonomic functions
  • Computerised EEG
  • Dermorphin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Electroencephalographic and autonomic effects of centrally administered dermorphin in rabbits. / Tartara, A.; Maurelli, M.; Marchioni, E.

In: Peptides, Vol. 6, No. SUPPL. 3, 1985, p. 143-147.

Research output: Contribution to journalArticle

Tartara, A. ; Maurelli, M. ; Marchioni, E. / Electroencephalographic and autonomic effects of centrally administered dermorphin in rabbits. In: Peptides. 1985 ; Vol. 6, No. SUPPL. 3. pp. 143-147.
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