Electroencephalographic coherence analysis in multiple sclerosis: Correlation with clinical, neuropsychological, and MRI findings

Research output: Contribution to journalArticle

Abstract

Objective - To explore functional corticocortical connections in multiple sclerosis by means of coherence of the EEG, and to evaluate their correlations with the degree of cognitive impairment and with brain lesion load assessed by MRT. Methods - EEG coherence was studied from 28 patients with clinically definite multiple sclerosis. Ten minutes of resting EEG were recorded with 20 scalp electrodes, with binaural reference. FFT power and coherence were calculated in artifact free epochs of 1 second and compared with values from 22 control subjects of comparable age and sex distribution. Patients also underwent MRI (n = 27) and neuropsychological examination (n = 21). Results - Compared with controls, patients with multiple sclerosis showed increased θ power in the frontotemporal-central regions (p <0.005). θ Band coherence was decreased between homologous areas (p <0.02). α Band coherence was decreased both in the local and long distance connections (p <0.0005). These findings were most striking both in patients with high MRI subcortical lesion load and in patients with cognitive involvement. A significant correlation was found between interhemispheric θ (p = 0.02) and α (p = 0.017) and anteroposterior α (p = 0.013) coherence and subcortical MRI lesion load, but not with exclusively periventricular lesion load. Conclusions - These findings support the hypothesis that cognitive impairment in multiple sclerosis is mostly dependent on involvement of corticocortical connections related to demyelination and/or axonal loss within the white matter immediately underlying the cortex.

Original languageEnglish
Pages (from-to)192-198
Number of pages7
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume69
Issue number2
DOIs
Publication statusPublished - Aug 2000

Fingerprint

Multiple Sclerosis
Electroencephalography
Sex Distribution
Age Distribution
Demyelinating Diseases
Scalp
Artifacts
Electrodes
Brain
Cognitive Dysfunction
Power (Psychology)

Keywords

  • Cognitive impairment
  • Coherence
  • Magnetic resonance imaging
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

@article{ecec3f5f60bc455aa150604db6695d19,
title = "Electroencephalographic coherence analysis in multiple sclerosis: Correlation with clinical, neuropsychological, and MRI findings",
abstract = "Objective - To explore functional corticocortical connections in multiple sclerosis by means of coherence of the EEG, and to evaluate their correlations with the degree of cognitive impairment and with brain lesion load assessed by MRT. Methods - EEG coherence was studied from 28 patients with clinically definite multiple sclerosis. Ten minutes of resting EEG were recorded with 20 scalp electrodes, with binaural reference. FFT power and coherence were calculated in artifact free epochs of 1 second and compared with values from 22 control subjects of comparable age and sex distribution. Patients also underwent MRI (n = 27) and neuropsychological examination (n = 21). Results - Compared with controls, patients with multiple sclerosis showed increased θ power in the frontotemporal-central regions (p <0.005). θ Band coherence was decreased between homologous areas (p <0.02). α Band coherence was decreased both in the local and long distance connections (p <0.0005). These findings were most striking both in patients with high MRI subcortical lesion load and in patients with cognitive involvement. A significant correlation was found between interhemispheric θ (p = 0.02) and α (p = 0.017) and anteroposterior α (p = 0.013) coherence and subcortical MRI lesion load, but not with exclusively periventricular lesion load. Conclusions - These findings support the hypothesis that cognitive impairment in multiple sclerosis is mostly dependent on involvement of corticocortical connections related to demyelination and/or axonal loss within the white matter immediately underlying the cortex.",
keywords = "Cognitive impairment, Coherence, Magnetic resonance imaging, Multiple sclerosis",
author = "Letizia Leocani and Tiziana Locatelli and Vittorio Martinelli and Marco Rovaris and Monica Falautano and Massimo Filippi and Giuseppe Magnani and Giancarlo Comi",
year = "2000",
month = "8",
doi = "10.1136/jnnp.69.2.192",
language = "English",
volume = "69",
pages = "192--198",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "2",

}

TY - JOUR

T1 - Electroencephalographic coherence analysis in multiple sclerosis

T2 - Correlation with clinical, neuropsychological, and MRI findings

AU - Leocani, Letizia

AU - Locatelli, Tiziana

AU - Martinelli, Vittorio

AU - Rovaris, Marco

AU - Falautano, Monica

AU - Filippi, Massimo

AU - Magnani, Giuseppe

AU - Comi, Giancarlo

PY - 2000/8

Y1 - 2000/8

N2 - Objective - To explore functional corticocortical connections in multiple sclerosis by means of coherence of the EEG, and to evaluate their correlations with the degree of cognitive impairment and with brain lesion load assessed by MRT. Methods - EEG coherence was studied from 28 patients with clinically definite multiple sclerosis. Ten minutes of resting EEG were recorded with 20 scalp electrodes, with binaural reference. FFT power and coherence were calculated in artifact free epochs of 1 second and compared with values from 22 control subjects of comparable age and sex distribution. Patients also underwent MRI (n = 27) and neuropsychological examination (n = 21). Results - Compared with controls, patients with multiple sclerosis showed increased θ power in the frontotemporal-central regions (p <0.005). θ Band coherence was decreased between homologous areas (p <0.02). α Band coherence was decreased both in the local and long distance connections (p <0.0005). These findings were most striking both in patients with high MRI subcortical lesion load and in patients with cognitive involvement. A significant correlation was found between interhemispheric θ (p = 0.02) and α (p = 0.017) and anteroposterior α (p = 0.013) coherence and subcortical MRI lesion load, but not with exclusively periventricular lesion load. Conclusions - These findings support the hypothesis that cognitive impairment in multiple sclerosis is mostly dependent on involvement of corticocortical connections related to demyelination and/or axonal loss within the white matter immediately underlying the cortex.

AB - Objective - To explore functional corticocortical connections in multiple sclerosis by means of coherence of the EEG, and to evaluate their correlations with the degree of cognitive impairment and with brain lesion load assessed by MRT. Methods - EEG coherence was studied from 28 patients with clinically definite multiple sclerosis. Ten minutes of resting EEG were recorded with 20 scalp electrodes, with binaural reference. FFT power and coherence were calculated in artifact free epochs of 1 second and compared with values from 22 control subjects of comparable age and sex distribution. Patients also underwent MRI (n = 27) and neuropsychological examination (n = 21). Results - Compared with controls, patients with multiple sclerosis showed increased θ power in the frontotemporal-central regions (p <0.005). θ Band coherence was decreased between homologous areas (p <0.02). α Band coherence was decreased both in the local and long distance connections (p <0.0005). These findings were most striking both in patients with high MRI subcortical lesion load and in patients with cognitive involvement. A significant correlation was found between interhemispheric θ (p = 0.02) and α (p = 0.017) and anteroposterior α (p = 0.013) coherence and subcortical MRI lesion load, but not with exclusively periventricular lesion load. Conclusions - These findings support the hypothesis that cognitive impairment in multiple sclerosis is mostly dependent on involvement of corticocortical connections related to demyelination and/or axonal loss within the white matter immediately underlying the cortex.

KW - Cognitive impairment

KW - Coherence

KW - Magnetic resonance imaging

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=0033940446&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033940446&partnerID=8YFLogxK

U2 - 10.1136/jnnp.69.2.192

DO - 10.1136/jnnp.69.2.192

M3 - Article

C2 - 10896692

AN - SCOPUS:0033940446

VL - 69

SP - 192

EP - 198

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 2

ER -