Electroencephalographic (EEG) Photoparoxysmal Responses under 5 Years of Age

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Abstract

Electroencephalographic (EEG) photoparoxysmal response has been little investigated in very young patients. We studied 5055 patients aged less than 5 years with no acquired brain damage, who underwent EEG recording. We determined the prevalence and significance of photoparoxysmal response induced by 1 to 20 Hz photic stimulation. Fifty-three showed photoparoxysmal response and were diagnosed as having Dravet syndrome (11), epileptic encephalopathy with myoclonic seizures (8), neurodegenerative disorders (8), benign idiopathic epilepsies (9), and static disorders with a known or suspected genetic origin (17). Photoparoxysmal response occurred in response to 1 to 5 Hz trains in 41.5% subjects. In most patients with epileptic encephalopathies, photoparoxysmal response was a transient finding: in 53.2%, it failed to be replicated in the recordings performed more than 6 months after initial evaluation. Photoparoxysmal response is rare in patients aged less than 5 years and has some peculiarities such as occurrence with low-frequency stimuli. Its distribution in specific conditions indicates that photoparoxysmal response may be useful in diagnostic workup.

Original languageEnglish
Pages (from-to)1824-1830
Number of pages7
JournalJournal of Child Neurology
Volume30
Issue number13
DOIs
Publication statusPublished - Nov 1 2015

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Myoclonic Epilepsy
Photic Stimulation
Brain Diseases
Neurodegenerative Diseases
Epilepsy
Seizures
Brain

Keywords

  • Dravet syndrome
  • genetic disorders
  • intermittent photic stimulation
  • neurodegenerative disorders
  • photoparoxysmal response

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Electroencephalographic (EEG) Photoparoxysmal Responses under 5 Years of Age",
abstract = "Electroencephalographic (EEG) photoparoxysmal response has been little investigated in very young patients. We studied 5055 patients aged less than 5 years with no acquired brain damage, who underwent EEG recording. We determined the prevalence and significance of photoparoxysmal response induced by 1 to 20 Hz photic stimulation. Fifty-three showed photoparoxysmal response and were diagnosed as having Dravet syndrome (11), epileptic encephalopathy with myoclonic seizures (8), neurodegenerative disorders (8), benign idiopathic epilepsies (9), and static disorders with a known or suspected genetic origin (17). Photoparoxysmal response occurred in response to 1 to 5 Hz trains in 41.5{\%} subjects. In most patients with epileptic encephalopathies, photoparoxysmal response was a transient finding: in 53.2{\%}, it failed to be replicated in the recordings performed more than 6 months after initial evaluation. Photoparoxysmal response is rare in patients aged less than 5 years and has some peculiarities such as occurrence with low-frequency stimuli. Its distribution in specific conditions indicates that photoparoxysmal response may be useful in diagnostic workup.",
keywords = "Dravet syndrome, genetic disorders, intermittent photic stimulation, neurodegenerative disorders, photoparoxysmal response",
author = "Simona Binelli and Francesca Ragona and Laura Canafoglia and Elena Freri and Veronica Saletti and Marina Casazza and Isabella Gilioli and Stefano D'Arrigo and Elisa Visani and Ferruccio Panzica and Tiziana Granata and Daria Riva and Silvana Franceschetti",
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T1 - Electroencephalographic (EEG) Photoparoxysmal Responses under 5 Years of Age

AU - Binelli, Simona

AU - Ragona, Francesca

AU - Canafoglia, Laura

AU - Freri, Elena

AU - Saletti, Veronica

AU - Casazza, Marina

AU - Gilioli, Isabella

AU - D'Arrigo, Stefano

AU - Visani, Elisa

AU - Panzica, Ferruccio

AU - Granata, Tiziana

AU - Riva, Daria

AU - Franceschetti, Silvana

PY - 2015/11/1

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