Electrogastrographyc activity in Parkinson's disease patients with and without motor fluctuations

Giovanni Albani, Nadia El Assawy, Stefania Cattaldo, Marilena De Gennaro, Francesca Gregorini, Luca Pradotto, Alessandro Mauro

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Gastroenteric dysfunctions are very common in Parkinson's disease, but their relationship with dopaminergic response and motor fluctuations is still unclear. Electrogastrography is a noninvasive method for measuring gastric myoelectrical activity. Methods:: We evaluated the effects of levodopa intake on the motility of empty stomachs in Parkinson's disease patients with and without motor fluctuations. Results:: The electrogastrography findings showed a normal pattern not influenced by levodopa intake, unrelated to plasmatic levodopa concentrations and to clinical parameters. Conclusions:: Our results suggest that at rest gastric activity of Parkinson's disease patients is normal and plasmatic levodopa variability is not influenced by gastric motility.

Original languageEnglish
Pages (from-to)1736-1740
Number of pages5
JournalMovement Disorders
Volume26
Issue number9
DOIs
Publication statusPublished - Aug 1 2011

Keywords

  • Gastric myoelectrical activity
  • L-dopa plasmatic levels
  • Motor fluctuations
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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