Electrolyte concentration during haemodialysis and QT interval prolongation in uraemic patients

Simonetta Genovesi, Chiara Dossi, Maria Rosa Viganò, Eleonora Galbiati, Federico Prolo, Andrea Stella, Marco Stramba-Badiale

Research output: Contribution to journalArticle

Abstract

Aims: To assess the effect of different combinations of potassium and calcium concentrations on QT interval in the dialysis bath in uraemic patients. Methods and results: Sixteen haemodialysis (HD) patients underwent a 24 h Holter recording before and during HD sessions with six randomized combinations of electrolytes concentrations of the dialysis bath (K+, 2 and 3 mmol/L; Ca2+, 1.25, 1.5, and 1.75 mmol/L). The effect of different dialysis baths on QT interval was significant (P <0.05). The longest mean QTc was observed with the lowest K+ (2 mmol/L) and Ca2+ concentrations (1.25 mmol/L), whereas the shortest mean QTc was observed with the highest K+ (3 mmol/L) and Ca2+ concentrations (1.75 mmol/L). QTc was >440 ms in 9 of 16 patients (56%) at the lowest Ca 2+ and K+ concentrations, and in 3 of 16 patients (18%) at the highest electrolytes level. Changes in QTc during the HD sessions were inversely correlated with that in total Ca and Ca2+ plasma concentrations (P <0.0001). Conclusion: Changes in ventricular repolarization duration associated with HD largely depend on the concentrations of Ca2+ and K+ in the dialysis bath. These findings may have important implications for the choice of the electrolytes concentration of the dialysis bath during the HD session.

Original languageEnglish
Pages (from-to)771-777
Number of pages7
JournalEuropace
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Calcium
  • Haemodialysis
  • Potassium
  • QT interval

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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