Electrolyte concentration during haemodialysis and QT interval prolongation in uraemic patients

Simonetta Genovesi, Chiara Dossi, Maria Rosa Viganò, Eleonora Galbiati, Federico Prolo, Andrea Stella, Marco Stramba-Badiale

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Aims: To assess the effect of different combinations of potassium and calcium concentrations on QT interval in the dialysis bath in uraemic patients. Methods and results: Sixteen haemodialysis (HD) patients underwent a 24 h Holter recording before and during HD sessions with six randomized combinations of electrolytes concentrations of the dialysis bath (K+, 2 and 3 mmol/L; Ca2+, 1.25, 1.5, and 1.75 mmol/L). The effect of different dialysis baths on QT interval was significant (P <0.05). The longest mean QTc was observed with the lowest K+ (2 mmol/L) and Ca2+ concentrations (1.25 mmol/L), whereas the shortest mean QTc was observed with the highest K+ (3 mmol/L) and Ca2+ concentrations (1.75 mmol/L). QTc was >440 ms in 9 of 16 patients (56%) at the lowest Ca 2+ and K+ concentrations, and in 3 of 16 patients (18%) at the highest electrolytes level. Changes in QTc during the HD sessions were inversely correlated with that in total Ca and Ca2+ plasma concentrations (P <0.0001). Conclusion: Changes in ventricular repolarization duration associated with HD largely depend on the concentrations of Ca2+ and K+ in the dialysis bath. These findings may have important implications for the choice of the electrolytes concentration of the dialysis bath during the HD session.

Original languageEnglish
Pages (from-to)771-777
Number of pages7
JournalEuropace
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 2008

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Baths
Electrolytes
Renal Dialysis
Dialysis
Potassium
Calcium

Keywords

  • Calcium
  • Haemodialysis
  • Potassium
  • QT interval

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Electrolyte concentration during haemodialysis and QT interval prolongation in uraemic patients. / Genovesi, Simonetta; Dossi, Chiara; Viganò, Maria Rosa; Galbiati, Eleonora; Prolo, Federico; Stella, Andrea; Stramba-Badiale, Marco.

In: Europace, Vol. 10, No. 6, 06.2008, p. 771-777.

Research output: Contribution to journalArticle

Genovesi, S, Dossi, C, Viganò, MR, Galbiati, E, Prolo, F, Stella, A & Stramba-Badiale, M 2008, 'Electrolyte concentration during haemodialysis and QT interval prolongation in uraemic patients', Europace, vol. 10, no. 6, pp. 771-777. https://doi.org/10.1093/europace/eun028
Genovesi S, Dossi C, Viganò MR, Galbiati E, Prolo F, Stella A et al. Electrolyte concentration during haemodialysis and QT interval prolongation in uraemic patients. Europace. 2008 Jun;10(6):771-777. https://doi.org/10.1093/europace/eun028
Genovesi, Simonetta ; Dossi, Chiara ; Viganò, Maria Rosa ; Galbiati, Eleonora ; Prolo, Federico ; Stella, Andrea ; Stramba-Badiale, Marco. / Electrolyte concentration during haemodialysis and QT interval prolongation in uraemic patients. In: Europace. 2008 ; Vol. 10, No. 6. pp. 771-777.
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