Electromagnetic field in control tissue regeneration, pelvic pain, neuro-inflammation & modulation of non-neuronal cells

S. E. Aragona, G. Mereghetti, G. Gianazza, A. Salsa, J. Lotti, A. Voza, T. Lotti, E. Canavesi

Research output: Contribution to journalArticlepeer-review


In scientific literature, magnetic fields are used both in basic science and clinical research. They are often used to treat pain and neuro-inflammation disorders thanks to their influence on cellular responses. Our project was born from the regenerative support that we wanted to give to those diseases characterized by neuroinflammation, nerve lesion, muscles and tissues disorders that can transform the symptom (e.g. neuropathic pelvic pain) in disease. In this study, we examined the action of pulsed electromagnetic fields (PEMFs) on skin lesion regeneration and the repetitive trans-pelvic magnetic stimulation (rTPMS) on patients affected by incontinence and post-surgical problems, sexual dysfunction, and pelvic pain. In rTPMS for post-surgery urinary incontinence, 40 patients affected by post-surgery urinary incontinence were enrolled. Twenty patients (post-prostatectomy) were treated with rTPMS and 20 with conventional therapies. In PEMF for the regeneration of skin tissue, 50 patients affected by various types of skin lesions (70% low legs vascular lesions) were treated with pulsed electromagnetic fields (PEMFs) twice per week and subsequently with home treatment (Home Care device) twice per day. In rTPMS study, results were evaluated after 3 months. In 10 patients (7 post prostatectomy, 3 cystourethrocele) which were submitted to 18 sessions, twice a week, an improvement of incontinence in 75% of cases with patient compliance was recorded and the quality of life up to 100% also improved. Utilizing PEMFs for the regeneration of skin tissue, following 3 months of AIMED protocol treatment, we reached a reduction of 50% of lesion area in the 60% of cases; 35% of cases healed completely. The use of rTPMS allows training muscles to adequately respond to inflammatory stimulus that causes muscle accommodation deficits with altered contractility or spastic painful contracture in pelvic district. It also stimulates a series of regenerative phenomena due to the action of magnetic waves at high intensity on cellular membrane and cytoplasm, especially on mast cells, which seem to have a fundamental role in the determination of the pelvic region pain. The magnetic fields for the treatment of cutaneous lesions, which are applied cyclically with other operating methods of AIMED protocol, confirmed the literature data, with a treated group of 50 patients. The use of magnetic fields opens new scenarios for regenerative medicine, since the cell could lend itself to a self-healing process if it receives specific information.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalJournal of Biological Regulators and Homeostatic Agents
Issue number2, Supplement 2
Publication statusPublished - Jun 1 2017


  • Neuroinflammation
  • Non-neuronal cells
  • Pelvic pain
  • Pulsed electromagnetic field
  • Tissue regeneration
  • Trans-pelvic magnetic stimulation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Physiology
  • Immunology
  • Oncology
  • Endocrinology
  • Physiology (medical)
  • Cancer Research


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