Electromotive administration of a new morphine formulation: Morphine citrate

R. Stephen, D. Miotti, R. Bettaglio, C. Rossi, C. Bonezzi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Two formulations of morphine citrate were synthesized: trimorphine citrate, 3(MH)+(C6H5O7)3- and morphine sodium citrate, 3(MH)+3Na+2(C6H5O7)3-. Four healthy individuals volunteered to undergo electromotive administration of the two formulations. Application of electric current (2 mA) to solutions of trimorphine citrate for 1 h resulted in iontophoretic transcutaneous administration of therapeutic quantities of morphine without deleterious reduction in the pH of the drug solutions. Application of a 2-mA current to solutions of morphine sodium citrate for 2 h resulted in combined iontophoretic and electrophoretic delivery of morphine with increased administration rates and an improved buffering capacity of the drug solutions.

Original languageEnglish
Pages (from-to)461-465
Number of pages5
JournalArtificial Organs
Volume18
Issue number6
Publication statusPublished - 1994

Fingerprint

Citric Acid
Morphine
Sodium
Cutaneous Administration
Electric currents
Pharmaceutical Preparations
sodium citrate
Therapeutics

Keywords

  • Administration
  • Citrate
  • Drug
  • Electromotive
  • Morphine
  • pH

ASJC Scopus subject areas

  • Biophysics

Cite this

Stephen, R., Miotti, D., Bettaglio, R., Rossi, C., & Bonezzi, C. (1994). Electromotive administration of a new morphine formulation: Morphine citrate. Artificial Organs, 18(6), 461-465.

Electromotive administration of a new morphine formulation : Morphine citrate. / Stephen, R.; Miotti, D.; Bettaglio, R.; Rossi, C.; Bonezzi, C.

In: Artificial Organs, Vol. 18, No. 6, 1994, p. 461-465.

Research output: Contribution to journalArticle

Stephen, R, Miotti, D, Bettaglio, R, Rossi, C & Bonezzi, C 1994, 'Electromotive administration of a new morphine formulation: Morphine citrate', Artificial Organs, vol. 18, no. 6, pp. 461-465.
Stephen, R. ; Miotti, D. ; Bettaglio, R. ; Rossi, C. ; Bonezzi, C. / Electromotive administration of a new morphine formulation : Morphine citrate. In: Artificial Organs. 1994 ; Vol. 18, No. 6. pp. 461-465.
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