Electron immunocytochemical localization of pepsinogen I (PgI) in chief cells, mucous-neck cells and transitional mucous-neck/chief cells, of the human fundic mucosa

M. Cornaggia, C. Capella, C. Riva, G. Finzi, E. Solcia

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Abstract

Specific PgI antibodies devoid of PgII cross reactivity have been applied to aldehyde-osmium fixed human, fundic-type, gastric mucosa investigated with the protein A-immunogold technique. PgI immunoreactivity has been detected in the homogeneous secretory granules of glandular chief cells, in bipartite granules of mucous-neck cells, in the granules of cells showing intermediate patterns and topography in between chief and mucous-neck cells (transitional cells), as well as in the granules of a few cells in the foveolar/mucous-neck boundary zone showing mixed foveolar/mucous-neck granule populations. The findings support progressive transformation of mucous-neck cells into chief cells.

Original languageEnglish
Pages (from-to)5-11
Number of pages7
JournalHistochemistry
Volume85
Issue number1
DOIs
Publication statusPublished - Jan 1986

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Pepsinogen A
Mucous Membrane
Neck
Electrons
Osmium
Secretory Vesicles
Staphylococcal Protein A
Gastric Mucosa
Aldehydes
Immunohistochemistry
Antibodies

ASJC Scopus subject areas

  • Anatomy
  • Medicine(all)

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Electron immunocytochemical localization of pepsinogen I (PgI) in chief cells, mucous-neck cells and transitional mucous-neck/chief cells, of the human fundic mucosa. / Cornaggia, M.; Capella, C.; Riva, C.; Finzi, G.; Solcia, E.

In: Histochemistry, Vol. 85, No. 1, 01.1986, p. 5-11.

Research output: Contribution to journalArticle

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