Electron immunocytochemical localization of pepsinogen I (PgI) in chief cells, mucous-neck cells and transitional mucous-neck/chief cells, of the human fundic mucosa

M. Cornaggia, C. Capella, C. Riva, G. Finzi, E. Solcia

Research output: Contribution to journalArticle

Abstract

Specific PgI antibodies devoid of PgII cross reactivity have been applied to aldehyde-osmium fixed human, fundic-type, gastric mucosa investigated with the protein A-immunogold technique. PgI immunoreactivity has been detected in the homogeneous secretory granules of glandular chief cells, in bipartite granules of mucous-neck cells, in the granules of cells showing intermediate patterns and topography in between chief and mucous-neck cells (transitional cells), as well as in the granules of a few cells in the foveolar/mucous-neck boundary zone showing mixed foveolar/mucous-neck granule populations. The findings support progressive transformation of mucous-neck cells into chief cells.

Original languageEnglish
Pages (from-to)5-11
Number of pages7
JournalHistochemistry
Volume85
Issue number1
DOIs
Publication statusPublished - Jan 1986

ASJC Scopus subject areas

  • Anatomy
  • Medicine(all)

Fingerprint Dive into the research topics of 'Electron immunocytochemical localization of pepsinogen I (PgI) in chief cells, mucous-neck cells and transitional mucous-neck/chief cells, of the human fundic mucosa'. Together they form a unique fingerprint.

  • Cite this