Electron microscopy of the remodelling process in hamstring tendon used as ACL graft

Stefano Zaffagnini; Viviana de Pasquale; Leonardo Marchesini Reggiani; Alessandro Russo; Patrizia Agati; Beatrice Bacchelli; Maurilio Marcacci

doi:10.1007/s00167-009-0925-7

Electron microscopy of the remodelling process in hamstring tendon used as ACL graft

Stefano Zaffagnini, Viviana de Pasquale, Leonardo Marchesini Reggiani, Alessandro Russo, Patrizia Agati, Beatrice Bacchelli, Maurilio Marcacci

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

The purpose of the present study was to make a histological analysis of the remodelling process of hamstring tendon graft used as Anterior Cruciate Ligament (ACL). The hamstring graft of eight patients was biopsied at different follow-up times from 1 to 10 years. The specimens were analysed with transmission electron microscopy (TEM) at ultrastructural level comparing them with a native ACL and a native hamstring graft. The hamstring graft was found to undergo ultrastructural changes in terms of number and diameter of fibrils with the major changes occurring in the first 2 years. At longer times after surgery (48 and 120 months) no important further changes were evident and the ultrastructure did not vary substantially from 2 to 10 years. In conclusion, the hamstring tendon used as ACL graft undergoes a transformation process but does not match the ultrastructure pattern of a normal ACL up to 10 years.

Original language	English
Pages (from-to)	1052-1058
Number of pages	7
Journal	Knee Surgery, Sports Traumatology, Arthroscopy
Volume	18
Issue number	8
DOIs	https://doi.org/10.1007/s00167-009-0925-7
Publication status	Published - 2010

Keywords

ACL reconstruction
Arthroscopy
Electron microscopy
Hamstring
Knee

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Surgery

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10.1007/s00167-009-0925-7

Cite this

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title = "Electron microscopy of the remodelling process in hamstring tendon used as ACL graft",

abstract = "The purpose of the present study was to make a histological analysis of the remodelling process of hamstring tendon graft used as Anterior Cruciate Ligament (ACL). The hamstring graft of eight patients was biopsied at different follow-up times from 1 to 10 years. The specimens were analysed with transmission electron microscopy (TEM) at ultrastructural level comparing them with a native ACL and a native hamstring graft. The hamstring graft was found to undergo ultrastructural changes in terms of number and diameter of fibrils with the major changes occurring in the first 2 years. At longer times after surgery (48 and 120 months) no important further changes were evident and the ultrastructure did not vary substantially from 2 to 10 years. In conclusion, the hamstring tendon used as ACL graft undergoes a transformation process but does not match the ultrastructure pattern of a normal ACL up to 10 years.",

keywords = "ACL reconstruction, Arthroscopy, Electron microscopy, Hamstring, Knee",

author = "Stefano Zaffagnini and {de Pasquale}, Viviana and Reggiani, {Leonardo Marchesini} and Alessandro Russo and Patrizia Agati and Beatrice Bacchelli and Maurilio Marcacci",

year = "2010",

doi = "10.1007/s00167-009-0925-7",

language = "English",

volume = "18",

pages = "1052--1058",

journal = "Knee Surgery, Sports Traumatology, Arthroscopy",

issn = "0942-2056",

publisher = "Springer Verlag",

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TY - JOUR

T1 - Electron microscopy of the remodelling process in hamstring tendon used as ACL graft

AU - Zaffagnini, Stefano

AU - de Pasquale, Viviana

AU - Reggiani, Leonardo Marchesini

AU - Russo, Alessandro

AU - Agati, Patrizia

AU - Bacchelli, Beatrice

AU - Marcacci, Maurilio

PY - 2010

Y1 - 2010

N2 - The purpose of the present study was to make a histological analysis of the remodelling process of hamstring tendon graft used as Anterior Cruciate Ligament (ACL). The hamstring graft of eight patients was biopsied at different follow-up times from 1 to 10 years. The specimens were analysed with transmission electron microscopy (TEM) at ultrastructural level comparing them with a native ACL and a native hamstring graft. The hamstring graft was found to undergo ultrastructural changes in terms of number and diameter of fibrils with the major changes occurring in the first 2 years. At longer times after surgery (48 and 120 months) no important further changes were evident and the ultrastructure did not vary substantially from 2 to 10 years. In conclusion, the hamstring tendon used as ACL graft undergoes a transformation process but does not match the ultrastructure pattern of a normal ACL up to 10 years.

AB - The purpose of the present study was to make a histological analysis of the remodelling process of hamstring tendon graft used as Anterior Cruciate Ligament (ACL). The hamstring graft of eight patients was biopsied at different follow-up times from 1 to 10 years. The specimens were analysed with transmission electron microscopy (TEM) at ultrastructural level comparing them with a native ACL and a native hamstring graft. The hamstring graft was found to undergo ultrastructural changes in terms of number and diameter of fibrils with the major changes occurring in the first 2 years. At longer times after surgery (48 and 120 months) no important further changes were evident and the ultrastructure did not vary substantially from 2 to 10 years. In conclusion, the hamstring tendon used as ACL graft undergoes a transformation process but does not match the ultrastructure pattern of a normal ACL up to 10 years.

KW - ACL reconstruction

KW - Arthroscopy

KW - Electron microscopy

KW - Hamstring

KW - Knee

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VL - 18

SP - 1052

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JO - Knee Surgery, Sports Traumatology, Arthroscopy

JF - Knee Surgery, Sports Traumatology, Arthroscopy

SN - 0942-2056

IS - 8

ER -

Electron microscopy of the remodelling process in hamstring tendon used as ACL graft

Abstract

Keywords

ASJC Scopus subject areas

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