Abstract
The purpose of the present study was to make a histological analysis of the remodelling process of hamstring tendon graft used as Anterior Cruciate Ligament (ACL). The hamstring graft of eight patients was biopsied at different follow-up times from 1 to 10 years. The specimens were analysed with transmission electron microscopy (TEM) at ultrastructural level comparing them with a native ACL and a native hamstring graft. The hamstring graft was found to undergo ultrastructural changes in terms of number and diameter of fibrils with the major changes occurring in the first 2 years. At longer times after surgery (48 and 120 months) no important further changes were evident and the ultrastructure did not vary substantially from 2 to 10 years. In conclusion, the hamstring tendon used as ACL graft undergoes a transformation process but does not match the ultrastructure pattern of a normal ACL up to 10 years.
| Original language | English |
|---|---|
| Pages (from-to) | 1052-1058 |
| Number of pages | 7 |
| Journal | Knee Surgery, Sports Traumatology, Arthroscopy |
| Volume | 18 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2010 |
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Keywords
- ACL reconstruction
- Arthroscopy
- Electron microscopy
- Hamstring
- Knee
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Surgery
Cite this
Electron microscopy of the remodelling process in hamstring tendon used as ACL graft. / Zaffagnini, Stefano; de Pasquale, Viviana; Reggiani, Leonardo Marchesini; Russo, Alessandro; Agati, Patrizia; Bacchelli, Beatrice; Marcacci, Maurilio.
In: Knee Surgery, Sports Traumatology, Arthroscopy, Vol. 18, No. 8, 2010, p. 1052-1058.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Electron microscopy of the remodelling process in hamstring tendon used as ACL graft
AU - Zaffagnini, Stefano
AU - de Pasquale, Viviana
AU - Reggiani, Leonardo Marchesini
AU - Russo, Alessandro
AU - Agati, Patrizia
AU - Bacchelli, Beatrice
AU - Marcacci, Maurilio
PY - 2010
Y1 - 2010
N2 - The purpose of the present study was to make a histological analysis of the remodelling process of hamstring tendon graft used as Anterior Cruciate Ligament (ACL). The hamstring graft of eight patients was biopsied at different follow-up times from 1 to 10 years. The specimens were analysed with transmission electron microscopy (TEM) at ultrastructural level comparing them with a native ACL and a native hamstring graft. The hamstring graft was found to undergo ultrastructural changes in terms of number and diameter of fibrils with the major changes occurring in the first 2 years. At longer times after surgery (48 and 120 months) no important further changes were evident and the ultrastructure did not vary substantially from 2 to 10 years. In conclusion, the hamstring tendon used as ACL graft undergoes a transformation process but does not match the ultrastructure pattern of a normal ACL up to 10 years.
AB - The purpose of the present study was to make a histological analysis of the remodelling process of hamstring tendon graft used as Anterior Cruciate Ligament (ACL). The hamstring graft of eight patients was biopsied at different follow-up times from 1 to 10 years. The specimens were analysed with transmission electron microscopy (TEM) at ultrastructural level comparing them with a native ACL and a native hamstring graft. The hamstring graft was found to undergo ultrastructural changes in terms of number and diameter of fibrils with the major changes occurring in the first 2 years. At longer times after surgery (48 and 120 months) no important further changes were evident and the ultrastructure did not vary substantially from 2 to 10 years. In conclusion, the hamstring tendon used as ACL graft undergoes a transformation process but does not match the ultrastructure pattern of a normal ACL up to 10 years.
KW - ACL reconstruction
KW - Arthroscopy
KW - Electron microscopy
KW - Hamstring
KW - Knee
UR - http://www.scopus.com/inward/record.url?scp=77954757017&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954757017&partnerID=8YFLogxK
U2 - 10.1007/s00167-009-0925-7
DO - 10.1007/s00167-009-0925-7
M3 - Article
C2 - 19787336
AN - SCOPUS:77954757017
VL - 18
SP - 1052
EP - 1058
JO - Knee Surgery, Sports Traumatology, Arthroscopy
JF - Knee Surgery, Sports Traumatology, Arthroscopy
SN - 0942-2056
IS - 8
ER -