Electrophysiologic characteristics in initiation of paroxysmal atrial fibrillation from a focal area

Ferdinand Kiemeneij, Patrick W. Serruys, Carlos Macaya, Wolfgang Rutsch, Guy Heyndrickx, Per Albertsson, Jean Fajadet, Victor Legrand, Pierre Materne, Jorge Belardi, Ulrich Sigwart, Antonio Colombo, Jean Jacques Goy, Clemens M C Disco, Marie Angèle Morel

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Abstract

OBJECTIVES: We investigated the electrophysiologic characteristics in the initiation of paroxysmal atrial fibrillation (PAF) from a focal area. BACKGROUND: The electrophysiologic characteristics in the initiation of PAF are still not clear. METHODS: The study group consisted of 77 patients (M/F = 65/12, age 66 ± 12 years) with frequent episodes of PAF; we analyzed: 1) 15 cycle lengths of electrical activity before the onset of atrial fibrillation (AF); 2) coupling interval (CI) of the first ectopic bear just before the initiation of AF; and 3) the prematurity of an ectopic beat (prematurity index [PI] = CI/mean of preceding 15 cycle lengths). RESULTS: A total of 111 episodes of sustained AF were identified. Two patterns of AF initiation were observed: group I (59/111, 53%) included the episodes preceded by cycle length oscillation, and group II (52/111, 47%) included the episodes initiated by a single ectopic beat with preceding cycle length relatively constant. The PI of group I episodes was significantly greater than that of group II (0.41 ± 0.12 vs. 0.34 ± 0.10, p <0.01). The CI (267 ± 54 ms vs. 217 ± 55 ms, p <0.05), AF1 (194 ± 36 ms vs. 153 ± 37 ms, p <0.05) and PI (0.49 ± 0.13 vs. 0.37 ± 0.11, p <0.01) of the AF episodes from the superior vena cava (SVC) were significantly longer and greater than those of AF episodes from pulmonary veins (PVs). CONCLUSIONS: In patients with PAF originating from PVs or the SVC, two major initiating patterns were found. Moreover, the electrophysiologic characteristics in the initiation of AF originating from the SVC were also different from those of AF initiating from the PVs.

Original languageEnglish
Pages (from-to)1658-1664
Number of pages7
JournalJournal of the American College of Cardiology
Volume37
Issue number6
DOIs
Publication statusPublished - 2001

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Atrial Fibrillation
Superior Vena Cava
Pulmonary Veins
Ursidae

ASJC Scopus subject areas

  • Nursing(all)

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Kiemeneij, F., Serruys, P. W., Macaya, C., Rutsch, W., Heyndrickx, G., Albertsson, P., ... Morel, M. A. (2001). Electrophysiologic characteristics in initiation of paroxysmal atrial fibrillation from a focal area. Journal of the American College of Cardiology, 37(6), 1658-1664. https://doi.org/10.1016/S0735-1097(01)01182-2

Electrophysiologic characteristics in initiation of paroxysmal atrial fibrillation from a focal area. / Kiemeneij, Ferdinand; Serruys, Patrick W.; Macaya, Carlos; Rutsch, Wolfgang; Heyndrickx, Guy; Albertsson, Per; Fajadet, Jean; Legrand, Victor; Materne, Pierre; Belardi, Jorge; Sigwart, Ulrich; Colombo, Antonio; Goy, Jean Jacques; Disco, Clemens M C; Morel, Marie Angèle.

In: Journal of the American College of Cardiology, Vol. 37, No. 6, 2001, p. 1658-1664.

Research output: Contribution to journalArticle

Kiemeneij, F, Serruys, PW, Macaya, C, Rutsch, W, Heyndrickx, G, Albertsson, P, Fajadet, J, Legrand, V, Materne, P, Belardi, J, Sigwart, U, Colombo, A, Goy, JJ, Disco, CMC & Morel, MA 2001, 'Electrophysiologic characteristics in initiation of paroxysmal atrial fibrillation from a focal area', Journal of the American College of Cardiology, vol. 37, no. 6, pp. 1658-1664. https://doi.org/10.1016/S0735-1097(01)01182-2
Kiemeneij, Ferdinand ; Serruys, Patrick W. ; Macaya, Carlos ; Rutsch, Wolfgang ; Heyndrickx, Guy ; Albertsson, Per ; Fajadet, Jean ; Legrand, Victor ; Materne, Pierre ; Belardi, Jorge ; Sigwart, Ulrich ; Colombo, Antonio ; Goy, Jean Jacques ; Disco, Clemens M C ; Morel, Marie Angèle. / Electrophysiologic characteristics in initiation of paroxysmal atrial fibrillation from a focal area. In: Journal of the American College of Cardiology. 2001 ; Vol. 37, No. 6. pp. 1658-1664.
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abstract = "OBJECTIVES: We investigated the electrophysiologic characteristics in the initiation of paroxysmal atrial fibrillation (PAF) from a focal area. BACKGROUND: The electrophysiologic characteristics in the initiation of PAF are still not clear. METHODS: The study group consisted of 77 patients (M/F = 65/12, age 66 ± 12 years) with frequent episodes of PAF; we analyzed: 1) 15 cycle lengths of electrical activity before the onset of atrial fibrillation (AF); 2) coupling interval (CI) of the first ectopic bear just before the initiation of AF; and 3) the prematurity of an ectopic beat (prematurity index [PI] = CI/mean of preceding 15 cycle lengths). RESULTS: A total of 111 episodes of sustained AF were identified. Two patterns of AF initiation were observed: group I (59/111, 53{\%}) included the episodes preceded by cycle length oscillation, and group II (52/111, 47{\%}) included the episodes initiated by a single ectopic beat with preceding cycle length relatively constant. The PI of group I episodes was significantly greater than that of group II (0.41 ± 0.12 vs. 0.34 ± 0.10, p <0.01). The CI (267 ± 54 ms vs. 217 ± 55 ms, p <0.05), AF1 (194 ± 36 ms vs. 153 ± 37 ms, p <0.05) and PI (0.49 ± 0.13 vs. 0.37 ± 0.11, p <0.01) of the AF episodes from the superior vena cava (SVC) were significantly longer and greater than those of AF episodes from pulmonary veins (PVs). CONCLUSIONS: In patients with PAF originating from PVs or the SVC, two major initiating patterns were found. Moreover, the electrophysiologic characteristics in the initiation of AF originating from the SVC were also different from those of AF initiating from the PVs.",
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T1 - Electrophysiologic characteristics in initiation of paroxysmal atrial fibrillation from a focal area

AU - Kiemeneij, Ferdinand

AU - Serruys, Patrick W.

AU - Macaya, Carlos

AU - Rutsch, Wolfgang

AU - Heyndrickx, Guy

AU - Albertsson, Per

AU - Fajadet, Jean

AU - Legrand, Victor

AU - Materne, Pierre

AU - Belardi, Jorge

AU - Sigwart, Ulrich

AU - Colombo, Antonio

AU - Goy, Jean Jacques

AU - Disco, Clemens M C

AU - Morel, Marie Angèle

PY - 2001

Y1 - 2001

N2 - OBJECTIVES: We investigated the electrophysiologic characteristics in the initiation of paroxysmal atrial fibrillation (PAF) from a focal area. BACKGROUND: The electrophysiologic characteristics in the initiation of PAF are still not clear. METHODS: The study group consisted of 77 patients (M/F = 65/12, age 66 ± 12 years) with frequent episodes of PAF; we analyzed: 1) 15 cycle lengths of electrical activity before the onset of atrial fibrillation (AF); 2) coupling interval (CI) of the first ectopic bear just before the initiation of AF; and 3) the prematurity of an ectopic beat (prematurity index [PI] = CI/mean of preceding 15 cycle lengths). RESULTS: A total of 111 episodes of sustained AF were identified. Two patterns of AF initiation were observed: group I (59/111, 53%) included the episodes preceded by cycle length oscillation, and group II (52/111, 47%) included the episodes initiated by a single ectopic beat with preceding cycle length relatively constant. The PI of group I episodes was significantly greater than that of group II (0.41 ± 0.12 vs. 0.34 ± 0.10, p <0.01). The CI (267 ± 54 ms vs. 217 ± 55 ms, p <0.05), AF1 (194 ± 36 ms vs. 153 ± 37 ms, p <0.05) and PI (0.49 ± 0.13 vs. 0.37 ± 0.11, p <0.01) of the AF episodes from the superior vena cava (SVC) were significantly longer and greater than those of AF episodes from pulmonary veins (PVs). CONCLUSIONS: In patients with PAF originating from PVs or the SVC, two major initiating patterns were found. Moreover, the electrophysiologic characteristics in the initiation of AF originating from the SVC were also different from those of AF initiating from the PVs.

AB - OBJECTIVES: We investigated the electrophysiologic characteristics in the initiation of paroxysmal atrial fibrillation (PAF) from a focal area. BACKGROUND: The electrophysiologic characteristics in the initiation of PAF are still not clear. METHODS: The study group consisted of 77 patients (M/F = 65/12, age 66 ± 12 years) with frequent episodes of PAF; we analyzed: 1) 15 cycle lengths of electrical activity before the onset of atrial fibrillation (AF); 2) coupling interval (CI) of the first ectopic bear just before the initiation of AF; and 3) the prematurity of an ectopic beat (prematurity index [PI] = CI/mean of preceding 15 cycle lengths). RESULTS: A total of 111 episodes of sustained AF were identified. Two patterns of AF initiation were observed: group I (59/111, 53%) included the episodes preceded by cycle length oscillation, and group II (52/111, 47%) included the episodes initiated by a single ectopic beat with preceding cycle length relatively constant. The PI of group I episodes was significantly greater than that of group II (0.41 ± 0.12 vs. 0.34 ± 0.10, p <0.01). The CI (267 ± 54 ms vs. 217 ± 55 ms, p <0.05), AF1 (194 ± 36 ms vs. 153 ± 37 ms, p <0.05) and PI (0.49 ± 0.13 vs. 0.37 ± 0.11, p <0.01) of the AF episodes from the superior vena cava (SVC) were significantly longer and greater than those of AF episodes from pulmonary veins (PVs). CONCLUSIONS: In patients with PAF originating from PVs or the SVC, two major initiating patterns were found. Moreover, the electrophysiologic characteristics in the initiation of AF originating from the SVC were also different from those of AF initiating from the PVs.

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