Electrophysiologic study of HIV-1 + patients without signs of peripheral neuropathy

Oscar Ronchi, Antonello Grippo, Paola Ghidini, Francesco Lolli, Mecocci Lorenzo, Massimo Di Pietro, Francesco Mazzotta

Research output: Contribution to journalArticle

Abstract

HIV-1 seropositive patients have a high frequency of nervous system diseases, and asymptomatic abnormalities are frequently detected. We studied 124 neurologically asymptomatic HIV-1 seropositive subjects and 23 normal control subjects by nerve conduction studies. No alterations were detectable in the asymptomatic stages of infection (CDC groups II and III), while subclinical peripheral nervous system (PNS) impairment was detected in symptomatic HIV-1 stages (CDC group IV). Specifically, in CDC group IV we observed a reduction in the motor conduction velocity of the deep peroneal nerve and the median nerve, and a similar reduction of the sensory conduction velocity of the sural nerve. There were no differences of the amplitude and area of the muscular response or of the sensory nerve action potential. As our patients did not present clinical or laboratory evidence for a toxic-dismetabolic etiology, our data indicate a progressive myelin damage more directly related to HIV-1 infection. This subclinical finding may have importance for the progression of the disease in the PNS.

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalJournal of the Neurological Sciences
Volume113
Issue number2
DOIs
Publication statusPublished - 1992

Keywords

  • AIDS
  • HIV-1
  • HIV-1 related neuropathy
  • Nerve conduction studies
  • Peripheral nervous system

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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