MSLT and immunogenetic findings in two unrelated Italian subjects with recurrent monosymptomatic hypersomnia are reported. In both patients MSLT documented a markedly increased daytime sleep propensity during the attacks without augmented REM sleep pressure. Both patients share the same HLA haplotype (HLA-DR1, DQ1) which has been found in Kleine-Levin syndrome. This makes these subtypes of recurrent hypersomnia indistinguishable one from the other, under the immunogenetic profile, but permits differentiation from narcolepsy which is HLA-DR2, DQ1 closely linked.
|Number of pages||3|
|Journal||Acta Neurologica Scandinavica|
|Publication status||Published - 1993|
- immunogenetic findings
- recurrent hypersomnia
ASJC Scopus subject areas
- Clinical Neurology