Electrophysiological and immunogenetic findings in recurrent monosymptomatic-type hypersomnia

A study of two unrelated Italian cases

R. Manni, M. Martinetti, M. T. Ratti, A. Tartara

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

MSLT and immunogenetic findings in two unrelated Italian subjects with recurrent monosymptomatic hypersomnia are reported. In both patients MSLT documented a markedly increased daytime sleep propensity during the attacks without augmented REM sleep pressure. Both patients share the same HLA haplotype (HLA-DR1, DQ1) which has been found in Kleine-Levin syndrome. This makes these subtypes of recurrent hypersomnia indistinguishable one from the other, under the immunogenetic profile, but permits differentiation from narcolepsy which is HLA-DR2, DQ1 closely linked.

Original languageEnglish
Pages (from-to)293-295
Number of pages3
JournalActa Neurologica Scandinavica
Volume88
Issue number4
Publication statusPublished - 1993

Fingerprint

Disorders of Excessive Somnolence
Immunogenetics
Kleine-Levin Syndrome
HLA-DR1 Antigen
HLA-DR2 Antigen
Narcolepsy
REM Sleep
Haplotypes
Sleep
Pressure
HLA-DQ1 antigen

Keywords

  • immunogenetic findings
  • MSLT
  • recurrent hypersomnia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Electrophysiological and immunogenetic findings in recurrent monosymptomatic-type hypersomnia : A study of two unrelated Italian cases. / Manni, R.; Martinetti, M.; Ratti, M. T.; Tartara, A.

In: Acta Neurologica Scandinavica, Vol. 88, No. 4, 1993, p. 293-295.

Research output: Contribution to journalArticle

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