Abstract
Objective This preliminary study investigated electrophysiological and microstructural features of sleep in children and adolescents 4–18 years of age who were born to depressed mothers. Methods A total of 31 healthy subjects (15 male and 16 female) participated in the study. In this sample, 20 children born to mothers diagnosed with Major Depressive Disorder (MDD) were designated as “high-risk”; 11 children born to mothers without a personal history of depression were designated as “low-risk.” Polysomnography including three-channel electroencephalography (EEG) was recorded for one night at the Pediatric Sleep Unit of the University Hospital of Lyon, France. Clinical and demographic data were collected. Sleep architectural parameters were analyzed. Sleep microstructure was assessed with the scoring of cyclic alternating pattern (CAP) and CAP measures were calculated. Spectral analysis was performed, and mean EEG band power was computed for each sleep stage. Sleep electrophysiological features (slow waves and sleep spindles) were detected, and related parameters were analyzed. Data were compared between high- and low-risk groups using Student t tests. Results A reduction in low-frequency spindle activity and slow spindles spatio-temporal characteristics over frontal and central derivations, and an altered distribution of CAP phase A subtypes (reduction of A1 over A2–3 ratio) were observed in the high-risk group relative to the low-risk group. Conclusion Limited spindles generation and increased non-rapid eye movement sleep instability, observed in children born to depressed mothers, might reflect functional anomalies in cortical plasticity that could represent a pathogenic factor or an epiphenomenon for MDD.
| Original language | English |
|---|---|
| Pages (from-to) | 95-103 |
| Number of pages | 9 |
| Journal | Sleep Medicine |
| Volume | 36 |
| DOIs | |
| Publication status | Published - Aug 1 2017 |
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Keywords
- Children
- Cyclic alternating pattern
- Depression
- Sleep
- Spindles
ASJC Scopus subject areas
- Medicine(all)
Cite this
Electrophysiological and microstructural features of sleep in children at high risk for depression : a preliminary study. / Sesso, Gianluca; Bat-Pitault, Flora; Guyon, Aurore; Plancoulaine, Sabine; Banfi, Tommaso; Milioli, Giulia; Parrino, Liborio; Faraguna, Ugo; Franco, Patricia.
In: Sleep Medicine, Vol. 36, 01.08.2017, p. 95-103.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Electrophysiological and microstructural features of sleep in children at high risk for depression
T2 - a preliminary study
AU - Sesso, Gianluca
AU - Bat-Pitault, Flora
AU - Guyon, Aurore
AU - Plancoulaine, Sabine
AU - Banfi, Tommaso
AU - Milioli, Giulia
AU - Parrino, Liborio
AU - Faraguna, Ugo
AU - Franco, Patricia
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Objective This preliminary study investigated electrophysiological and microstructural features of sleep in children and adolescents 4–18 years of age who were born to depressed mothers. Methods A total of 31 healthy subjects (15 male and 16 female) participated in the study. In this sample, 20 children born to mothers diagnosed with Major Depressive Disorder (MDD) were designated as “high-risk”; 11 children born to mothers without a personal history of depression were designated as “low-risk.” Polysomnography including three-channel electroencephalography (EEG) was recorded for one night at the Pediatric Sleep Unit of the University Hospital of Lyon, France. Clinical and demographic data were collected. Sleep architectural parameters were analyzed. Sleep microstructure was assessed with the scoring of cyclic alternating pattern (CAP) and CAP measures were calculated. Spectral analysis was performed, and mean EEG band power was computed for each sleep stage. Sleep electrophysiological features (slow waves and sleep spindles) were detected, and related parameters were analyzed. Data were compared between high- and low-risk groups using Student t tests. Results A reduction in low-frequency spindle activity and slow spindles spatio-temporal characteristics over frontal and central derivations, and an altered distribution of CAP phase A subtypes (reduction of A1 over A2–3 ratio) were observed in the high-risk group relative to the low-risk group. Conclusion Limited spindles generation and increased non-rapid eye movement sleep instability, observed in children born to depressed mothers, might reflect functional anomalies in cortical plasticity that could represent a pathogenic factor or an epiphenomenon for MDD.
AB - Objective This preliminary study investigated electrophysiological and microstructural features of sleep in children and adolescents 4–18 years of age who were born to depressed mothers. Methods A total of 31 healthy subjects (15 male and 16 female) participated in the study. In this sample, 20 children born to mothers diagnosed with Major Depressive Disorder (MDD) were designated as “high-risk”; 11 children born to mothers without a personal history of depression were designated as “low-risk.” Polysomnography including three-channel electroencephalography (EEG) was recorded for one night at the Pediatric Sleep Unit of the University Hospital of Lyon, France. Clinical and demographic data were collected. Sleep architectural parameters were analyzed. Sleep microstructure was assessed with the scoring of cyclic alternating pattern (CAP) and CAP measures were calculated. Spectral analysis was performed, and mean EEG band power was computed for each sleep stage. Sleep electrophysiological features (slow waves and sleep spindles) were detected, and related parameters were analyzed. Data were compared between high- and low-risk groups using Student t tests. Results A reduction in low-frequency spindle activity and slow spindles spatio-temporal characteristics over frontal and central derivations, and an altered distribution of CAP phase A subtypes (reduction of A1 over A2–3 ratio) were observed in the high-risk group relative to the low-risk group. Conclusion Limited spindles generation and increased non-rapid eye movement sleep instability, observed in children born to depressed mothers, might reflect functional anomalies in cortical plasticity that could represent a pathogenic factor or an epiphenomenon for MDD.
KW - Children
KW - Cyclic alternating pattern
KW - Depression
KW - Sleep
KW - Spindles
UR - http://www.scopus.com/inward/record.url?scp=85021683732&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021683732&partnerID=8YFLogxK
U2 - 10.1016/j.sleep.2017.05.013
DO - 10.1016/j.sleep.2017.05.013
M3 - Article
AN - SCOPUS:85021683732
VL - 36
SP - 95
EP - 103
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
ER -