Electrophysiological and SD-OCT findings in patients receiving chloroquine therapy in relation to cumulative dosage and duration of treatment

Federica Bertoli, Maja Šuštar, Martina Jarc Vidmar, Darko Perovšek, Jelka Brecelj, Špela Markelj, Polona Jaki Mekjavić, Daša Šuput, Matija Tomšič, Miriam Isola, Claudio Battistella, Paolo Lanzetta, Marko Hawlina

Research output: Contribution to journalArticle

Abstract

Purpose: Assessment of multifocal ERG (mfERG) changes in patients treated with chloroquine and their correlation with morphological abnormalities, detected by spectral-domain optical coherence tomography in relation to cumulative dosage. Methods: Data from 37 eyes of 20 patients were retrospectively collected, and one randomly selected eye per patient was considered for statistical analysis. Eyes were divided into three groups according to mfERG and visual acuity findings: normal, early and advanced maculopathy. Functional measures of the first three mfERG rings were compared with retinal thickness measures of the corresponding OCT ETDRS circles. Data on cumulative dose and duration of therapy were also evaluated. Results: The mean mfERG values progressively decreased according to the stage of the disease. In particular in the early maculopathy group, amplitudes were significantly reduced in all the three central rings. The mean ring ratio R1/R2 was abnormal only in the early maculopathy group. OCT thickness measures were significantly lower in all the three ETDRS circles in the advanced maculopathy group, and in the paracentral circle in the early maculopathy group. Considering all the eyes, there was a statistically significant correlation between functional and morphological values (p < 0.001). High chloroquine cumulative dosages were always associated with retinal toxic effects, whereas lower cumulative dosages generated different levels of toxicity. Conclusions: This study shows a strong association between mfERG ring values and the corresponding OCT thickness measures; however, mfERG may enhance early detection of functional changes in patients treated with chloroquine, especially in ambiguous cases. At low chloroquine cumulative dosages, different subjects might have different susceptibilities to the drug.

Original languageEnglish
JournalDocumenta Ophthalmologica
DOIs
Publication statusAccepted/In press - Jan 1 2020
Externally publishedYes

Keywords

  • Chloroquine
  • Cumulative dosage
  • Maculopathy
  • Multifocal ERG
  • Optical coherence tomography
  • Toxicity

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Electrophysiological and SD-OCT findings in patients receiving chloroquine therapy in relation to cumulative dosage and duration of treatment'. Together they form a unique fingerprint.

  • Cite this

    Bertoli, F., Šuštar, M., Jarc Vidmar, M., Perovšek, D., Brecelj, J., Markelj, Š., Jaki Mekjavić, P., Šuput, D., Tomšič, M., Isola, M., Battistella, C., Lanzetta, P., & Hawlina, M. (Accepted/In press). Electrophysiological and SD-OCT findings in patients receiving chloroquine therapy in relation to cumulative dosage and duration of treatment. Documenta Ophthalmologica. https://doi.org/10.1007/s10633-019-09744-0