Electrophysiological changes of cardiac function during antidepressant treatment

Michela Sala, Matteo Lazzaretti, Giulia De Vidovich, Edgardo Caverzasi, Francesco Barale, Giorgio d'Allio, Paolo Brambilla

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Some antidepressant agents can cause electrophysiological changes of cardiac function leading to ventricular arrhythmias and sudden death. However, antidepressants have also protective effects on the heart through their capacity to modulate cardiac autonomic-mediated physiological responses. Heart rate variability and QTc length are two strictly linked parameters that allow us to appreciate the effects of different drugs on cardiac physiology. Heart rate variability reflects functioning of the autonomic nervous system and possibly also regulation by the limbic system. Autonomic regulation of cardiac activity influences also cardiac repolarization and QT length, both directly and via its effects on heart rate. In this review we present the methodologies adopted to study the effect of antidepressant drugs on QT length and heart rate variability and we summarize data on electrophysiological changes related to antidepressant treatment. Clinical implications for the choice of different antidepressants in different clinical populations are discussed.

Original languageEnglish
Pages (from-to)29-43
Number of pages15
JournalTherapeutic Advances in Cardiovascular Disease
Volume3
Issue number1
DOIs
Publication statusPublished - 2009

Fingerprint

Antidepressive Agents
Heart Rate
Limbic System
Autonomic Nervous System
Sudden Death
Cardiac Arrhythmias
Pharmaceutical Preparations
Population

Keywords

  • Heart rate
  • Long-QT syndrome
  • Tachyarrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Electrophysiological changes of cardiac function during antidepressant treatment. / Sala, Michela; Lazzaretti, Matteo; De Vidovich, Giulia; Caverzasi, Edgardo; Barale, Francesco; d'Allio, Giorgio; Brambilla, Paolo.

In: Therapeutic Advances in Cardiovascular Disease, Vol. 3, No. 1, 2009, p. 29-43.

Research output: Contribution to journalArticle

Sala, Michela ; Lazzaretti, Matteo ; De Vidovich, Giulia ; Caverzasi, Edgardo ; Barale, Francesco ; d'Allio, Giorgio ; Brambilla, Paolo. / Electrophysiological changes of cardiac function during antidepressant treatment. In: Therapeutic Advances in Cardiovascular Disease. 2009 ; Vol. 3, No. 1. pp. 29-43.
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