Electrophysiological (EEG, BAEP, VEP) study in patients with beta-thalassemia major.

G. Amabile, E. Stefano, I. Bianco, M. C. Aliquo, P. Giunti, F. Pierelli, P. A. Rizzo, C. Morocutti

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Twenty-four patients affected by beta-thalassemia major were studied by means of combined EEG, VEP and BAEP recordings. All the subjects were treated with regular blood transfusions and chelating therapy (DFO). An elevated incidence of EEG abnormalities (70.8%) consisting of diffused slow waves and/or diffused small sharp spikes was seen. VEP P100 latency was abnormally prolonged in eight patients (33.3%). Furthermore, a voltage increase of N75-P100 (29%) and P100-N145 (33.3%) VEP components was observed. Mean latency and voltage values were significantly increased when compared with those of a control group. No BAEP alterations were observed. No correlations were found between electrophysiological data, serum ferritin levels and transfusional treatment duration. The possible mechanisms involved in provoking such electrophysiological abnormalities are discussed.

Original languageEnglish
Pages (from-to)181-190
Number of pages10
JournalActa Neurologica Belgica
Volume87
Issue number4
Publication statusPublished - Aug 1987

Fingerprint

beta-Thalassemia
Electroencephalography
Ferritins
Blood Transfusion
Control Groups
Incidence
Therapeutics
Serum

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Amabile, G., Stefano, E., Bianco, I., Aliquo, M. C., Giunti, P., Pierelli, F., ... Morocutti, C. (1987). Electrophysiological (EEG, BAEP, VEP) study in patients with beta-thalassemia major. Acta Neurologica Belgica, 87(4), 181-190.

Electrophysiological (EEG, BAEP, VEP) study in patients with beta-thalassemia major. / Amabile, G.; Stefano, E.; Bianco, I.; Aliquo, M. C.; Giunti, P.; Pierelli, F.; Rizzo, P. A.; Morocutti, C.

In: Acta Neurologica Belgica, Vol. 87, No. 4, 08.1987, p. 181-190.

Research output: Contribution to journalArticle

Amabile, G, Stefano, E, Bianco, I, Aliquo, MC, Giunti, P, Pierelli, F, Rizzo, PA & Morocutti, C 1987, 'Electrophysiological (EEG, BAEP, VEP) study in patients with beta-thalassemia major.', Acta Neurologica Belgica, vol. 87, no. 4, pp. 181-190.
Amabile G, Stefano E, Bianco I, Aliquo MC, Giunti P, Pierelli F et al. Electrophysiological (EEG, BAEP, VEP) study in patients with beta-thalassemia major. Acta Neurologica Belgica. 1987 Aug;87(4):181-190.
Amabile, G. ; Stefano, E. ; Bianco, I. ; Aliquo, M. C. ; Giunti, P. ; Pierelli, F. ; Rizzo, P. A. ; Morocutti, C. / Electrophysiological (EEG, BAEP, VEP) study in patients with beta-thalassemia major. In: Acta Neurologica Belgica. 1987 ; Vol. 87, No. 4. pp. 181-190.
@article{861ab97f65b34e71ab303850d401d96c,
title = "Electrophysiological (EEG, BAEP, VEP) study in patients with beta-thalassemia major.",
abstract = "Twenty-four patients affected by beta-thalassemia major were studied by means of combined EEG, VEP and BAEP recordings. All the subjects were treated with regular blood transfusions and chelating therapy (DFO). An elevated incidence of EEG abnormalities (70.8{\%}) consisting of diffused slow waves and/or diffused small sharp spikes was seen. VEP P100 latency was abnormally prolonged in eight patients (33.3{\%}). Furthermore, a voltage increase of N75-P100 (29{\%}) and P100-N145 (33.3{\%}) VEP components was observed. Mean latency and voltage values were significantly increased when compared with those of a control group. No BAEP alterations were observed. No correlations were found between electrophysiological data, serum ferritin levels and transfusional treatment duration. The possible mechanisms involved in provoking such electrophysiological abnormalities are discussed.",
author = "G. Amabile and E. Stefano and I. Bianco and Aliquo, {M. C.} and P. Giunti and F. Pierelli and Rizzo, {P. A.} and C. Morocutti",
year = "1987",
month = "8",
language = "English",
volume = "87",
pages = "181--190",
journal = "Acta Neurologica Belgica",
issn = "0300-9108",
publisher = "Springer-Verlag Italia",
number = "4",

}

TY - JOUR

T1 - Electrophysiological (EEG, BAEP, VEP) study in patients with beta-thalassemia major.

AU - Amabile, G.

AU - Stefano, E.

AU - Bianco, I.

AU - Aliquo, M. C.

AU - Giunti, P.

AU - Pierelli, F.

AU - Rizzo, P. A.

AU - Morocutti, C.

PY - 1987/8

Y1 - 1987/8

N2 - Twenty-four patients affected by beta-thalassemia major were studied by means of combined EEG, VEP and BAEP recordings. All the subjects were treated with regular blood transfusions and chelating therapy (DFO). An elevated incidence of EEG abnormalities (70.8%) consisting of diffused slow waves and/or diffused small sharp spikes was seen. VEP P100 latency was abnormally prolonged in eight patients (33.3%). Furthermore, a voltage increase of N75-P100 (29%) and P100-N145 (33.3%) VEP components was observed. Mean latency and voltage values were significantly increased when compared with those of a control group. No BAEP alterations were observed. No correlations were found between electrophysiological data, serum ferritin levels and transfusional treatment duration. The possible mechanisms involved in provoking such electrophysiological abnormalities are discussed.

AB - Twenty-four patients affected by beta-thalassemia major were studied by means of combined EEG, VEP and BAEP recordings. All the subjects were treated with regular blood transfusions and chelating therapy (DFO). An elevated incidence of EEG abnormalities (70.8%) consisting of diffused slow waves and/or diffused small sharp spikes was seen. VEP P100 latency was abnormally prolonged in eight patients (33.3%). Furthermore, a voltage increase of N75-P100 (29%) and P100-N145 (33.3%) VEP components was observed. Mean latency and voltage values were significantly increased when compared with those of a control group. No BAEP alterations were observed. No correlations were found between electrophysiological data, serum ferritin levels and transfusional treatment duration. The possible mechanisms involved in provoking such electrophysiological abnormalities are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0023392479&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023392479&partnerID=8YFLogxK

M3 - Article

VL - 87

SP - 181

EP - 190

JO - Acta Neurologica Belgica

JF - Acta Neurologica Belgica

SN - 0300-9108

IS - 4

ER -