In this paper we studied the effects of lamotrigine (LTG), GP 47779 (the active metabolite of oxcarbazepine) and FBM on field potentials recorded from prefrontal and frontal cortical slices in the presence of physiological concentrations of magnesium (1.2 mM) or in Mg++-free. LTG and GP 47779 decreased in a dose-depended manner, the field potentials amplitude under both experimental conditions. FBM caused a dose-related decrease of field potentials amplitude only in the absence of magnesium. This study shows that different mechanisms of action are involved in the drug-induced reduction of the cortico-cortical excitatory transmission.
|Translated title of the contribution||Electrophysiological effects of lamotrigine, oxcarbazepine and felbamate on prefrontal and frontal cortical slices of rat|
|Number of pages||6|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1996|
ASJC Scopus subject areas
- Clinical Neurology