Effetti elettrofisiologici della lamotrigina, oxcarbazepina e felbamato in fettine di corteccia prefrontale e frontale di ratto

A. Siniscalchi; P. Calabresi; N. B. Mercuri; A. Stefani; G. Bernardi

Effetti elettrofisiologici della lamotrigina, oxcarbazepina e felbamato in fettine di corteccia prefrontale e frontale di ratto

Translated title of the contribution: Electrophysiological effects of lamotrigine, oxcarbazepine and felbamate on prefrontal and frontal cortical slices of rat

A. Siniscalchi, P. Calabresi, N. B. Mercuri, A. Stefani, G. Bernardi

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

In this paper we studied the effects of lamotrigine (LTG), GP 47779 (the active metabolite of oxcarbazepine) and FBM on field potentials recorded from prefrontal and frontal cortical slices in the presence of physiological concentrations of magnesium (1.2 mM) or in Mg++-free. LTG and GP 47779 decreased in a dose-depended manner, the field potentials amplitude under both experimental conditions. FBM caused a dose-related decrease of field potentials amplitude only in the absence of magnesium. This study shows that different mechanisms of action are involved in the drug-induced reduction of the cortico-cortical excitatory transmission.

Translated title of the contribution	Electrophysiological effects of lamotrigine, oxcarbazepine and felbamate on prefrontal and frontal cortical slices of rat
Original language	Italian
Pages (from-to)	149-154
Number of pages	6
Journal	Bollettino - Lega Italiana contro l'Epilessia
Issue number	95-96
Publication status	Published - 1996

ASJC Scopus subject areas

Clinical Neurology

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title = "Effetti elettrofisiologici della lamotrigina, oxcarbazepina e felbamato in fettine di corteccia prefrontale e frontale di ratto",

abstract = "In this paper we studied the effects of lamotrigine (LTG), GP 47779 (the active metabolite of oxcarbazepine) and FBM on field potentials recorded from prefrontal and frontal cortical slices in the presence of physiological concentrations of magnesium (1.2 mM) or in Mg++-free. LTG and GP 47779 decreased in a dose-depended manner, the field potentials amplitude under both experimental conditions. FBM caused a dose-related decrease of field potentials amplitude only in the absence of magnesium. This study shows that different mechanisms of action are involved in the drug-induced reduction of the cortico-cortical excitatory transmission.",

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author = "A. Siniscalchi and P. Calabresi and Mercuri, {N. B.} and A. Stefani and G. Bernardi",

year = "1996",

language = "Italian",

pages = "149--154",

journal = "Bollettino - Lega Italiana contro l'Epilessia",

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T1 - Effetti elettrofisiologici della lamotrigina, oxcarbazepina e felbamato in fettine di corteccia prefrontale e frontale di ratto

AU - Siniscalchi, A.

AU - Calabresi, P.

AU - Mercuri, N. B.

AU - Stefani, A.

AU - Bernardi, G.

PY - 1996

Y1 - 1996

N2 - In this paper we studied the effects of lamotrigine (LTG), GP 47779 (the active metabolite of oxcarbazepine) and FBM on field potentials recorded from prefrontal and frontal cortical slices in the presence of physiological concentrations of magnesium (1.2 mM) or in Mg++-free. LTG and GP 47779 decreased in a dose-depended manner, the field potentials amplitude under both experimental conditions. FBM caused a dose-related decrease of field potentials amplitude only in the absence of magnesium. This study shows that different mechanisms of action are involved in the drug-induced reduction of the cortico-cortical excitatory transmission.

AB - In this paper we studied the effects of lamotrigine (LTG), GP 47779 (the active metabolite of oxcarbazepine) and FBM on field potentials recorded from prefrontal and frontal cortical slices in the presence of physiological concentrations of magnesium (1.2 mM) or in Mg++-free. LTG and GP 47779 decreased in a dose-depended manner, the field potentials amplitude under both experimental conditions. FBM caused a dose-related decrease of field potentials amplitude only in the absence of magnesium. This study shows that different mechanisms of action are involved in the drug-induced reduction of the cortico-cortical excitatory transmission.

KW - Antiepileptic drugs

KW - Epilepsy

KW - Frontal lobe

KW - Rat

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JO - Bollettino - Lega Italiana contro l'Epilessia

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