Effetti elettrofisiologici della lamotrigina, oxcarbazepina e felbamato in fettine di corteccia prefrontale e frontale di ratto

Translated title of the contribution: Electrophysiological effects of lamotrigine, oxcarbazepine and felbamate on prefrontal and frontal cortical slices of rat

A. Siniscalchi, P. Calabresi, N. B. Mercuri, A. Stefani, G. Bernardi

Research output: Contribution to journalArticlepeer-review

Abstract

In this paper we studied the effects of lamotrigine (LTG), GP 47779 (the active metabolite of oxcarbazepine) and FBM on field potentials recorded from prefrontal and frontal cortical slices in the presence of physiological concentrations of magnesium (1.2 mM) or in Mg++-free. LTG and GP 47779 decreased in a dose-depended manner, the field potentials amplitude under both experimental conditions. FBM caused a dose-related decrease of field potentials amplitude only in the absence of magnesium. This study shows that different mechanisms of action are involved in the drug-induced reduction of the cortico-cortical excitatory transmission.

Translated title of the contributionElectrophysiological effects of lamotrigine, oxcarbazepine and felbamate on prefrontal and frontal cortical slices of rat
Original languageItalian
Pages (from-to)149-154
Number of pages6
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number95-96
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Clinical Neurology

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