Electrophysiological evaluation of visual pathways in paclitaxel-treated patients

V. Scaioli, A. Caraceni, C. Martini, S. Curzi, G. Capri, G. Luca

Research output: Contribution to journalArticle

Abstract

As paclitaxel may induce positive spontaneous visual symptoms or persistent visual loss, we carried out this electrophysiological study in an attempt to clarify the underlying pathophysiological mechanisms of visual pathway involvement. The study involved 30 breast cancer patients: 14 were treated with paclitaxel alone (group A) and 16 with paclitaxel and adriamycin (group B). Pattern visual evoked potentials (VEPs), and transient, 30 Hz flicker (FLK) and oscillatory potential (OP) white flash electroretinograms (ERGs), were recorded before treatment, after the third and sixth therapeutic cycle, and at the end of the programmed regimen. Pretreatment: Abnormal VEP and OP and FLK changes occurred more than 75% of patients; transient ERGs were normal in more than 90%. Serial recordings: VEPs remained unchanged in both goups. In group A, ERG b-wave latency significantly increased (ANOVA P

Original languageEnglish
Pages (from-to)79-87
Number of pages9
JournalJournal of Neuro-Oncology
Volume77
Issue number1
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Chemotherapy
  • Electroretinogram
  • Ocular toxicity
  • Paclitaxel
  • Tamoxifen
  • Visual evoked potentials

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neuroscience(all)

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