Electrophysiological evaluation of visual pathways in paclitaxel-treated patients

V. Scaioli; A. Caraceni; C. Martini; S. Curzi; G. Capri; G. Luca

doi:10.1007/s11060-005-9008-x

Electrophysiological evaluation of visual pathways in paclitaxel-treated patients

V. Scaioli, A. Caraceni, C. Martini, S. Curzi, G. Capri, G. Luca

Research output: Contribution to journal › Article › peer-review

Abstract

As paclitaxel may induce positive spontaneous visual symptoms or persistent visual loss, we carried out this electrophysiological study in an attempt to clarify the underlying pathophysiological mechanisms of visual pathway involvement. The study involved 30 breast cancer patients: 14 were treated with paclitaxel alone (group A) and 16 with paclitaxel and adriamycin (group B). Pattern visual evoked potentials (VEPs), and transient, 30 Hz flicker (FLK) and oscillatory potential (OP) white flash electroretinograms (ERGs), were recorded before treatment, after the third and sixth therapeutic cycle, and at the end of the programmed regimen. Pretreatment: Abnormal VEP and OP and FLK changes occurred more than 75% of patients; transient ERGs were normal in more than 90%. Serial recordings: VEPs remained unchanged in both goups. In group A, ERG b-wave latency significantly increased (ANOVA P

Original language	English
Pages (from-to)	79-87
Number of pages	9
Journal	Journal of Neuro-Oncology
Volume	77
Issue number	1
DOIs	https://doi.org/10.1007/s11060-005-9008-x
Publication status	Published - Mar 2006

Keywords

Chemotherapy
Electroretinogram
Ocular toxicity
Paclitaxel
Tamoxifen
Visual evoked potentials

ASJC Scopus subject areas

Clinical Neurology
Cancer Research
Oncology
Neuroscience(all)

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10.1007/s11060-005-9008-x

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abstract = "As paclitaxel may induce positive spontaneous visual symptoms or persistent visual loss, we carried out this electrophysiological study in an attempt to clarify the underlying pathophysiological mechanisms of visual pathway involvement. The study involved 30 breast cancer patients: 14 were treated with paclitaxel alone (group A) and 16 with paclitaxel and adriamycin (group B). Pattern visual evoked potentials (VEPs), and transient, 30 Hz flicker (FLK) and oscillatory potential (OP) white flash electroretinograms (ERGs), were recorded before treatment, after the third and sixth therapeutic cycle, and at the end of the programmed regimen. Pretreatment: Abnormal VEP and OP and FLK changes occurred more than 75% of patients; transient ERGs were normal in more than 90%. Serial recordings: VEPs remained unchanged in both goups. In group A, ERG b-wave latency significantly increased (ANOVA P ",

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AU - Caraceni, A.

AU - Martini, C.

AU - Curzi, S.

AU - Capri, G.

AU - Luca, G.

PY - 2006/3

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N2 - As paclitaxel may induce positive spontaneous visual symptoms or persistent visual loss, we carried out this electrophysiological study in an attempt to clarify the underlying pathophysiological mechanisms of visual pathway involvement. The study involved 30 breast cancer patients: 14 were treated with paclitaxel alone (group A) and 16 with paclitaxel and adriamycin (group B). Pattern visual evoked potentials (VEPs), and transient, 30 Hz flicker (FLK) and oscillatory potential (OP) white flash electroretinograms (ERGs), were recorded before treatment, after the third and sixth therapeutic cycle, and at the end of the programmed regimen. Pretreatment: Abnormal VEP and OP and FLK changes occurred more than 75% of patients; transient ERGs were normal in more than 90%. Serial recordings: VEPs remained unchanged in both goups. In group A, ERG b-wave latency significantly increased (ANOVA P

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KW - Chemotherapy

KW - Electroretinogram

KW - Ocular toxicity

KW - Paclitaxel

KW - Tamoxifen

KW - Visual evoked potentials

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Electrophysiological evaluation of visual pathways in paclitaxel-treated patients

Abstract

Keywords

ASJC Scopus subject areas

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