Electrophysiological evidence for trigeminal neuron sensitization in patients with migraine

Giorgio Sandrini, Alberto Proietti Cecchini, Ivan Milanov, Cristina Tassorelli, Maria Gabriella Buzzi, Giuseppe Nappi

Research output: Contribution to journalArticle

Abstract

The electrically elicited corneal reflex is a useful tool for exploring the trigeminal system in humans and it may provide additional evidence pointing to a dysfunction of this system in migrainous patients. Tactile perception, corneal reflex and pain thresholds were studied in 48 migraine without aura patients during pain-free periods and compared with those observed in 24 controls. Twenty-eight of the patients had strictly unilateral headache, while the other 20 had bilateral or side-shifting pain during attacks. Both migraine subgroups (bilateral and unilateral) showed significantly lower thresholds compared with controls. The lowest values were observed on the symptomatic side of unilateral migraine patients. These findings suggest that sensorimotor mechanisms and/or pain control systems at the trigeminal level are impaired in migraine. The bilateral location of these abnormalities seems to point to a centrally located dysfunction.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalNeuroscience Letters
Volume317
Issue number3
DOIs
Publication statusPublished - Jan 14 2002

Fingerprint

Migraine Disorders
Neurons
Blinking
Touch Perception
Migraine without Aura
Pain
Pain Threshold
Headache

Keywords

  • Blink reflex
  • Corneal reflex
  • Migraine
  • Pain perception
  • Tactile perception
  • Trigeminal pain pathway

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Electrophysiological evidence for trigeminal neuron sensitization in patients with migraine. / Sandrini, Giorgio; Proietti Cecchini, Alberto; Milanov, Ivan; Tassorelli, Cristina; Buzzi, Maria Gabriella; Nappi, Giuseppe.

In: Neuroscience Letters, Vol. 317, No. 3, 14.01.2002, p. 135-138.

Research output: Contribution to journalArticle

Sandrini, Giorgio ; Proietti Cecchini, Alberto ; Milanov, Ivan ; Tassorelli, Cristina ; Buzzi, Maria Gabriella ; Nappi, Giuseppe. / Electrophysiological evidence for trigeminal neuron sensitization in patients with migraine. In: Neuroscience Letters. 2002 ; Vol. 317, No. 3. pp. 135-138.
@article{b98fce0266b84ab5b0140160dd74bb8b,
title = "Electrophysiological evidence for trigeminal neuron sensitization in patients with migraine",
abstract = "The electrically elicited corneal reflex is a useful tool for exploring the trigeminal system in humans and it may provide additional evidence pointing to a dysfunction of this system in migrainous patients. Tactile perception, corneal reflex and pain thresholds were studied in 48 migraine without aura patients during pain-free periods and compared with those observed in 24 controls. Twenty-eight of the patients had strictly unilateral headache, while the other 20 had bilateral or side-shifting pain during attacks. Both migraine subgroups (bilateral and unilateral) showed significantly lower thresholds compared with controls. The lowest values were observed on the symptomatic side of unilateral migraine patients. These findings suggest that sensorimotor mechanisms and/or pain control systems at the trigeminal level are impaired in migraine. The bilateral location of these abnormalities seems to point to a centrally located dysfunction.",
keywords = "Blink reflex, Corneal reflex, Migraine, Pain perception, Tactile perception, Trigeminal pain pathway",
author = "Giorgio Sandrini and {Proietti Cecchini}, Alberto and Ivan Milanov and Cristina Tassorelli and Buzzi, {Maria Gabriella} and Giuseppe Nappi",
year = "2002",
month = "1",
day = "14",
doi = "10.1016/S0304-3940(01)02447-8",
language = "English",
volume = "317",
pages = "135--138",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Electrophysiological evidence for trigeminal neuron sensitization in patients with migraine

AU - Sandrini, Giorgio

AU - Proietti Cecchini, Alberto

AU - Milanov, Ivan

AU - Tassorelli, Cristina

AU - Buzzi, Maria Gabriella

AU - Nappi, Giuseppe

PY - 2002/1/14

Y1 - 2002/1/14

N2 - The electrically elicited corneal reflex is a useful tool for exploring the trigeminal system in humans and it may provide additional evidence pointing to a dysfunction of this system in migrainous patients. Tactile perception, corneal reflex and pain thresholds were studied in 48 migraine without aura patients during pain-free periods and compared with those observed in 24 controls. Twenty-eight of the patients had strictly unilateral headache, while the other 20 had bilateral or side-shifting pain during attacks. Both migraine subgroups (bilateral and unilateral) showed significantly lower thresholds compared with controls. The lowest values were observed on the symptomatic side of unilateral migraine patients. These findings suggest that sensorimotor mechanisms and/or pain control systems at the trigeminal level are impaired in migraine. The bilateral location of these abnormalities seems to point to a centrally located dysfunction.

AB - The electrically elicited corneal reflex is a useful tool for exploring the trigeminal system in humans and it may provide additional evidence pointing to a dysfunction of this system in migrainous patients. Tactile perception, corneal reflex and pain thresholds were studied in 48 migraine without aura patients during pain-free periods and compared with those observed in 24 controls. Twenty-eight of the patients had strictly unilateral headache, while the other 20 had bilateral or side-shifting pain during attacks. Both migraine subgroups (bilateral and unilateral) showed significantly lower thresholds compared with controls. The lowest values were observed on the symptomatic side of unilateral migraine patients. These findings suggest that sensorimotor mechanisms and/or pain control systems at the trigeminal level are impaired in migraine. The bilateral location of these abnormalities seems to point to a centrally located dysfunction.

KW - Blink reflex

KW - Corneal reflex

KW - Migraine

KW - Pain perception

KW - Tactile perception

KW - Trigeminal pain pathway

UR - http://www.scopus.com/inward/record.url?scp=0037074122&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037074122&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(01)02447-8

DO - 10.1016/S0304-3940(01)02447-8

M3 - Article

C2 - 11755258

AN - SCOPUS:0037074122

VL - 317

SP - 135

EP - 138

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -