Electrophysiological response patterns ofprimary sensory cortices in migraine

Anna Ambrosini, J. Schoenen

Research output: Contribution to journalArticlepeer-review


Migraine is an ictal disorder characterised by a particular vulnerability of patients to sensoryoverload, both during and outsideof the attack. Central nervous system dysfunctions are supposed toplay a pivotal role in migraine. Electroneurophysiological methods, which aim to investigate sensory processing, seem thus particularly appropriate to study the pathophysiology of migraine. We have thus reviewed evoked potential studies performed in migraine patients. Although results are in part contradictory, these studies nonetheless demonstrate an interictal dysfunction of sensory cortices,and possibly of subcortical structures, in migraine with and without aura. The predominant abnormalityis a deficient habituation of evoked responses to repeated stimuli, probably due to cortical, and possibly widespread neural, "dysexcitability".

Original languageEnglish
Pages (from-to)377-388
Number of pages12
JournalJournal of Headache and Pain
Issue number6
Publication statusPublished - Dec 2006


  • Cortical excitability
  • Evoked potentials
  • Migraine
  • Pathophysiology
  • Sensory cortices

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Neuroscience(all)


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