Electrophysiological study of neurologically asymptomatic HIV1 seropositive patients

A. Ragazzoni, A. Grippo, P. Ghidini, V. Schiavone, F. Lolli, F. Mazzotta, L. Mecocci, F. Pinto

Research output: Contribution to journalArticlepeer-review


EEGs, brainstem auditory evoked potentials (BAEPs) and auditory event-related potentials (ERPs) were recorded from 33 individuals infected with the human immunodeficiency virus, type 1 (HIV1+ patients: 13 CDC Class II or III; 20 Class IV). All were neurologically asymptomatic, non-demented, and has a past history of intravenous drug abuse. Sixteen age- and sex-matched normals and 10 HIV1- former drug addicts served as controls. Half of the HIV1+ and HIV1- subjects displayed mild EEG anomalies and, except for one HIV+ patient, BAEPs were normal in both groups. ERPs were normal in all HIV1- subjects but anomalous (longer latencies of components P2, N2, P3; reduced amplitude of P3) in 9 HIV1+ patients (27%), the incidence of such anomalies being higher for Class IV than Class II/III patients. Auditory ERPs proved the most sensitive and specific of these electrophysiological procedures in detecting subclinical central nervous system involvement in HIV1 infection.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalActa Neurologica Scandinavica
Issue number1
Publication statusPublished - 1993


  • BAEPs
  • Drug addiction
  • EEGs
  • Electrophysiology
  • ERPs
  • HIV1 infection

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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