TY - JOUR
T1 - Electroporation-based treatments in minimally invasive percutaneous, laparoscopy and endoscopy procedures for treatment of deep-seated tumors
AU - Granata, V.
AU - Fusco, R.
AU - D'alessio, V.
AU - Giannini, A.
AU - Venanzio Setola, S.
AU - Belli, A.
AU - Palaia, R.
AU - Petrillo, A.
AU - Izzo, F.
N1 - Funding Information:
The research was founded by PROJECT F/050140/01-03/ X32 IGEA/SPES MEDICA/PASCALEINSTITUTE, Fund for Sustainable Growth-Call HORIZON 2020 PON I&C 2014-2020, entitled "DEEP-cancers:Deployable-expandable Electrode for ElectroPoration of cancer cells".
Publisher Copyright:
© 2021 Verduci Editore s.r.l. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Electroporation (EP) techniques, used alone (Irreversible Electroporation, IRE) or in combination with anti-cancer drugs (Electrochemotherapy, ECT), have been shown to be effective in the treatment of several types of cancers. The efficacy of ECT and IRE is well demonstrated for the treatment of non-superficial tumor metastases, and it depends on the applied electrical parameters. Particularly, ECT is an effective local therapy that uses electroporation to enhance the cytotoxic effect of bleomycin or cisplatin injected intravenously or intratumorally. Pre-clinical investigations to test alternative anti-cancer drugs, explore new combinations of treatment modalities, and evaluate different sets of pulse protocols for effective tissue electroporation, are ongoing. Further ECT developments include the treatment of deep-seated tumors with percutaneous, laparoscopy, and endoscopy approaches, with the aim of establishing a less invasive approach. ECT is highly effective in the treatment of tumors of any histology, in minimizing the damage of critical normal tissue or organs, and in reducing pain and muscular contractions. This work describes the new technological advances in the field of ECT treatment for deep-seated tumors.
AB - Electroporation (EP) techniques, used alone (Irreversible Electroporation, IRE) or in combination with anti-cancer drugs (Electrochemotherapy, ECT), have been shown to be effective in the treatment of several types of cancers. The efficacy of ECT and IRE is well demonstrated for the treatment of non-superficial tumor metastases, and it depends on the applied electrical parameters. Particularly, ECT is an effective local therapy that uses electroporation to enhance the cytotoxic effect of bleomycin or cisplatin injected intravenously or intratumorally. Pre-clinical investigations to test alternative anti-cancer drugs, explore new combinations of treatment modalities, and evaluate different sets of pulse protocols for effective tissue electroporation, are ongoing. Further ECT developments include the treatment of deep-seated tumors with percutaneous, laparoscopy, and endoscopy approaches, with the aim of establishing a less invasive approach. ECT is highly effective in the treatment of tumors of any histology, in minimizing the damage of critical normal tissue or organs, and in reducing pain and muscular contractions. This work describes the new technological advances in the field of ECT treatment for deep-seated tumors.
KW - Deep-seated tumors
KW - Electrochemotherapy
KW - Endoscopy
KW - Irreversible electroporation
KW - Laparoscopy
KW - Percutaneous
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U2 - 10.26355/eurrev_202105_25836
DO - 10.26355/eurrev_202105_25836
M3 - Article
C2 - 34002828
AN - SCOPUS:85106632573
VL - 25
SP - 3536
EP - 3545
JO - European Review for Medical and Pharmacological Sciences
JF - European Review for Medical and Pharmacological Sciences
SN - 1128-3602
IS - 9
ER -