Electroporation of bone tissue: Implications for use in the treatment of bone metastasis with electrochemotherapy

R. Cadossi, M. Fini, M. Ronchetti, F. De Terlizzi, F. Cavani

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Electrical pulses were applied to the distal femur of rabbits by inserting four electrodes in order to evaluate if and to what extent cell electroporation could be achieved in such a non-homogenous tissue. Dose response effect of number of pulses delivered was observed. 120 pulses at 1750V/cm successfully removed all osteogenetic activity among the electrodes, as evidenced by tetracyclin staining. These preclinical results lay the foundation for use of electroporation in the treatment of bone metastases.

Original languageEnglish
Title of host publicationIFMBE Proceedings
Pages8-9
Number of pages2
Volume25
Edition13
DOIs
Publication statusPublished - 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Special Topics and Workshops - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Special Topics and Workshops
CountryGermany
CityMunich
Period9/7/099/12/09

Keywords

  • Bone metastasis
  • Electrochemotherapy
  • Electroporation
  • Tetracycline
  • Tumour ablation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Fingerprint Dive into the research topics of 'Electroporation of bone tissue: Implications for use in the treatment of bone metastasis with electrochemotherapy'. Together they form a unique fingerprint.

Cite this