Electroporation of bone tissue: Implications for use in the treatment of bone metastasis with electrochemotherapy

R. Cadossi; M. Fini; M. Ronchetti; F. De Terlizzi; F. Cavani

doi:10.1007/978-3-642-03895-2-3

Electroporation of bone tissue: Implications for use in the treatment of bone metastasis with electrochemotherapy

R. Cadossi, M. Fini, M. Ronchetti, F. De Terlizzi, F. Cavani

Istituti Ortopedici Rizzoli

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Electrical pulses were applied to the distal femur of rabbits by inserting four electrodes in order to evaluate if and to what extent cell electroporation could be achieved in such a non-homogenous tissue. Dose response effect of number of pulses delivered was observed. 120 pulses at 1750V/cm successfully removed all osteogenetic activity among the electrodes, as evidenced by tetracyclin staining. These preclinical results lay the foundation for use of electroporation in the treatment of bone metastases.

Original language	English
Title of host publication	IFMBE Proceedings
Pages	8-9
Number of pages	2
Volume	25
Edition	13
DOIs	https://doi.org/10.1007/978-3-642-03895-2-3
Publication status	Published - 2009
Event	World Congress on Medical Physics and Biomedical Engineering: Special Topics and Workshops - Munich, Germany Duration: Sep 7 2009 → Sep 12 2009

Other

Other	World Congress on Medical Physics and Biomedical Engineering: Special Topics and Workshops
Country/Territory	Germany
City	Munich
Period	9/7/09 → 9/12/09

Keywords

Bone metastasis
Electrochemotherapy
Electroporation
Tetracycline
Tumour ablation

ASJC Scopus subject areas

Biomedical Engineering
Bioengineering

Access to Document

10.1007/978-3-642-03895-2-3

Cite this

Cadossi, R, Fini, M, Ronchetti, M, De Terlizzi, F & Cavani, F 2009, Electroporation of bone tissue: Implications for use in the treatment of bone metastasis with electrochemotherapy. in IFMBE Proceedings. 13 edn, vol. 25, pp. 8-9, World Congress on Medical Physics and Biomedical Engineering: Special Topics and Workshops, Munich, Germany, 9/7/09. https://doi.org/10.1007/978-3-642-03895-2-3

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AU - Cavani, F.

PY - 2009

Y1 - 2009

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AB - Electrical pulses were applied to the distal femur of rabbits by inserting four electrodes in order to evaluate if and to what extent cell electroporation could be achieved in such a non-homogenous tissue. Dose response effect of number of pulses delivered was observed. 120 pulses at 1750V/cm successfully removed all osteogenetic activity among the electrodes, as evidenced by tetracyclin staining. These preclinical results lay the foundation for use of electroporation in the treatment of bone metastases.

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KW - Electrochemotherapy

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KW - Tetracycline

KW - Tumour ablation

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Y2 - 7 September 2009 through 12 September 2009

ER -

Electroporation of bone tissue: Implications for use in the treatment of bone metastasis with electrochemotherapy

Abstract

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Keywords

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