Abstract
Electrical pulses were applied to the distal femur of rabbits by inserting four electrodes in order to evaluate if and to what extent cell electroporation could be achieved in such a non-homogenous tissue. Dose response effect of number of pulses delivered was observed. 120 pulses at 1750V/cm successfully removed all osteogenetic activity among the electrodes, as evidenced by tetracyclin staining. These preclinical results lay the foundation for use of electroporation in the treatment of bone metastases.
Original language | English |
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Title of host publication | IFMBE Proceedings |
Pages | 8-9 |
Number of pages | 2 |
Volume | 25 |
Edition | 13 |
DOIs | |
Publication status | Published - 2009 |
Event | World Congress on Medical Physics and Biomedical Engineering: Special Topics and Workshops - Munich, Germany Duration: Sep 7 2009 → Sep 12 2009 |
Other
Other | World Congress on Medical Physics and Biomedical Engineering: Special Topics and Workshops |
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Country/Territory | Germany |
City | Munich |
Period | 9/7/09 → 9/12/09 |
Keywords
- Bone metastasis
- Electrochemotherapy
- Electroporation
- Tetracycline
- Tumour ablation
ASJC Scopus subject areas
- Biomedical Engineering
- Bioengineering