Our knowledge of the fundamental mechanisms underlying epileptiform discharges has been greatly advanced by the use of in vitro preparation such as cultured and acutely dissociated neurons or brain slices. In particular, the in vitro brain slice preparation has made it possible to study at cellular, pharmacological and molecular levels neurons and glia cells that retain their original connections. The rilevance of the mechanisms discovered in animal models for understanding the physiopathogenesis of the human epileptic syndromes depends on the demonstrations that such mechanisms do occur in the human condition as well. In this paper we shall briefly report some of the findings that have been gathered to date in the brain slices obtained from patients opertated at the Montreal Neurological Institute. These patients include cases of temporal lobe epilepsy and those with focal cortical dysplasia. We shall elaborate on some of the possible implications that the reported findings might have in the characterization of neocortical tissue obtained from patients with neuronal migration disorders.
|Number of pages||7|
|Journal||Giornale di Neuropsicofarmacologia|
|Publication status||Published - Jul 1996|
ASJC Scopus subject areas
- Pharmaceutical Science
- Neuropsychology and Physiological Psychology