Aim: Intraventricular haemorrhage (IVH) is the most common variety of cerebral haemorrhage and cause of neurological disabilities in preterm newborns. We evaluated the usefulness of urine Activin A concentrations for the early detection of perinatal IVH. Methods: We conducted a case-control study on 100 preterm newborns (20 with IVH and 80 without IVH) in whom urine Activin A was measured at five predetermined time-points in the first 72 h after birth. IVH diagnosis and the extension of the lesion were performed by ultrasound scanning within the first 72 h and at 1 week after birth, respectively. Results: Urine Activin A in infants who developed IVH was significantly higher than in controls at all monitoring time-points (p <0.01 for all), increasing progressively from first urination to 24 h when it reached the highest peak (p <0.001). At a cut-off 0.08 ng/L, at the first void, Activin A sensitivity and specificity were 68.7% (CI: 41.3-89%) and 84.5% (CI: 75-91.5%). Conclusion: Activin A measurements in urine soon after birth can constitute a promising tool for identifying preterm infants at risk of IVH.
|Journal||Acta Paediatrica, International Journal of Paediatrics|
|Publication status||Published - Oct 2013|
- Activin A
- Brain damage
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health