Elevated circulating levels of inflammatory cytokines and bacterial endotoxin in adults with congenital heart disease

Rakesh Sharma, Aidan P. Bolger, Wei Li, Periklis A. Davlouros, Hans Dieter Volk, Philip A. Poole-Wilson, Andrew J S Coats, Michael A. Gatzoulis, Stefan D. Anker

Research output: Contribution to journalArticle

Abstract

Chronic heart failure is a state of immune activation, and endotoxin is a potential trigger for cytokine production. Our aim was to study whether immune activation and endotoxemia occur in adults with congenital heart disease. We prospectively measured tumor necrosis factor (TNF)-α, soluble TNF receptors (sTNFR-1, sTNFR-2), interleukin-6, interleukin-10, endotoxin, and soluble CD14 levels in 52 consecutive adults with congenital heart disease (age 34 ± 2 years [mean ± SEM]) and 18 healthy controls (age 31 ± 1 years). A variety of congenital heart lesions were studied: single ventricle physiology (n = 15), systemic right ventricle (n = 7), tetralogy of Fallot (n = 20), and "other" congenital heart disease (n = 10). Patients were subgrouped into asymptomatic (New York Heart Association [NYHA] class I, n = 11), mild (NYHA class II, n = 30), and moderate/severe (NYHA class III/IV, n = 11) categories. Patients had elevated TNF and interleukin-6 levels compared with controls (TNF 2.8 vs 2.1 pg/ml, p

Original languageEnglish
Pages (from-to)188-193
Number of pages6
JournalThe American Journal of Cardiology
Volume92
Issue number2
DOIs
Publication statusPublished - Jul 15 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Sharma, R., Bolger, A. P., Li, W., Davlouros, P. A., Volk, H. D., Poole-Wilson, P. A., Coats, A. J. S., Gatzoulis, M. A., & Anker, S. D. (2003). Elevated circulating levels of inflammatory cytokines and bacterial endotoxin in adults with congenital heart disease. The American Journal of Cardiology, 92(2), 188-193. https://doi.org/10.1016/S0002-9149(03)00536-8