Elevated concentrations of liver enzymes and ferritin identify a new phenotype of insulin resistance: Effect of weight loss after gastric banding

Amalia Gastaldelli, Lucia Perego, Michele Paganelli, Giorgio Sesti, Marta Hribal, Alberto O. Chavez, Ralph A. DeFronzo, Antonio Pontiroli, Franco Folli

Research output: Contribution to journalArticle

Abstract

Background: Several studies have associated elevated liver enzymes (LFTs), obesity, and type 2 diabetes (T2DM), and a link has been established between insulin resistance (IR) and elevated ferritin concentrations. We examined the relationship between LFTs, ferritin, and IR in morbid obese subjects and the effect of weight loss after bariatric surgery. Methods: We measured liver enzymes, ferritin, insulin resistance, and glucose tolerance (by OGTT) in 159 morbid obese subjects (BMI=44.4±0.4 kg/m2) at baseline, 6 months and 1 year after laparoscopic-adjustable-gastric banding (LAGB). Subjects were divided in two groups: increased LFTs (ALT>30; AST/ALT

Original languageEnglish
Pages (from-to)80-86
Number of pages7
JournalObesity Surgery
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2009

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Ferritins
Insulin Resistance
Weight Loss
Stomach
Phenotype
Liver
Enzymes
Bariatric Surgery
Glucose Tolerance Test
Type 2 Diabetes Mellitus
Obesity
Glucose

ASJC Scopus subject areas

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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Elevated concentrations of liver enzymes and ferritin identify a new phenotype of insulin resistance : Effect of weight loss after gastric banding. / Gastaldelli, Amalia; Perego, Lucia; Paganelli, Michele; Sesti, Giorgio; Hribal, Marta; Chavez, Alberto O.; DeFronzo, Ralph A.; Pontiroli, Antonio; Folli, Franco.

In: Obesity Surgery, Vol. 19, No. 1, 01.2009, p. 80-86.

Research output: Contribution to journalArticle

Gastaldelli, Amalia ; Perego, Lucia ; Paganelli, Michele ; Sesti, Giorgio ; Hribal, Marta ; Chavez, Alberto O. ; DeFronzo, Ralph A. ; Pontiroli, Antonio ; Folli, Franco. / Elevated concentrations of liver enzymes and ferritin identify a new phenotype of insulin resistance : Effect of weight loss after gastric banding. In: Obesity Surgery. 2009 ; Vol. 19, No. 1. pp. 80-86.
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AU - Paganelli, Michele

AU - Sesti, Giorgio

AU - Hribal, Marta

AU - Chavez, Alberto O.

AU - DeFronzo, Ralph A.

AU - Pontiroli, Antonio

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