Elevated e-cadherin and α/β-catenin expression after androgen deprivation therapy in prostate adenocarcinoma

Carlo Patriarca, D. Petrella, B. Campo, P. Colombo, P. Giunta, M. Parente, N. Zucchini, R. Mazzucchelli, R. Montironi

Research output: Contribution to journalArticlepeer-review

Abstract

The histological patterns of anti-androgen-treated prostate adenocarcinoma mimic high grade tumors classified according to the widely used Gleason scoring system. However, the biological characteristics of anti-androgen treated carcinoma are largely unknown. E-cadherin, α-catenin, and β-catenin adhesion molecules are down-regulated in pharmacologically untreated high grade prostate carcinoma. In this study, we used immunohistochemical techniques to investigate their expression in twenty acinar adenocarcinomas after anti-androgen therapy in prostatectomy specimens. After adrogen ablation therapy, expression of all these adhesion molecules was higher than that of pretreatment biopsies of the same patient group and high grade matched untreated controls. These results emphasize the inaccuracy of the Gleason score for anti-androgen-treated prostate adenocarcinoma and the more differentiated phenotype of prostate adenocarcinoma after anti-hormonal therapy.

Original languageEnglish
Pages (from-to)659-665
Number of pages7
JournalPathology Research and Practice
Volume199
Issue number10
DOIs
Publication statusPublished - 2003

Keywords

  • Alpha/beta catenins
  • Antiandrogen
  • E-cadherin
  • Prostate adenocarcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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