Abstract
Context: Elevated heart rate has been associated with insulin resistance and incident type 2 diabetes but its relationship with β-cell function is not known. Our aim was to investigate whether baseline heart rate is associated with β-cell function and hyperglycaemia. Methods: We used the prospective RISC cohort with 1005 non-diabetic individuals who had an oral glucose tolerance test (OGTT) at baseline and after 3 years. Impaired glucose regulation was defined as a fasting plasma glucose ≥6.1 mmol/l or a 2-h plasma glucose ≥7.8 mmol/l. Insulin sensitivity was assessed by the OGIS index and insulin secretion and b-cell glucose sensitivity at both baseline and 3 years. Results: Baseline heart rate was positively related to both fasting (P
Original language | English |
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Pages (from-to) | 409-415 |
Number of pages | 7 |
Journal | European Journal of Endocrinology |
Volume | 173 |
Issue number | 3 |
DOIs | |
Publication status | Published - Sep 1 2015 |
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Medicine(all)