Elevated heart rate predicts β cell function in non-diabetic individuals: The RISC cohort

Fabrice Bonnet; Jean Philippe Empana; Andrea Natali; Lucilla Monti; Alain Golay; Katarina Lalic; Jacqueline Dekker; Andrea Mari; Beverley Balkau

doi:10.1530/EJE-15-0115

Elevated heart rate predicts β cell function in non-diabetic individuals: The RISC cohort

Fabrice Bonnet, Jean Philippe Empana, Andrea Natali, Lucilla Monti, Alain Golay, Katarina Lalic, Jacqueline Dekker, Andrea Mari, Beverley Balkau

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Context: Elevated heart rate has been associated with insulin resistance and incident type 2 diabetes but its relationship with β-cell function is not known. Our aim was to investigate whether baseline heart rate is associated with β-cell function and hyperglycaemia. Methods: We used the prospective RISC cohort with 1005 non-diabetic individuals who had an oral glucose tolerance test (OGTT) at baseline and after 3 years. Impaired glucose regulation was defined as a fasting plasma glucose ≥6.1 mmol/l or a 2-h plasma glucose ≥7.8 mmol/l. Insulin sensitivity was assessed by the OGIS index and insulin secretion and b-cell glucose sensitivity at both baseline and 3 years. Results: Baseline heart rate was positively related to both fasting (P

Original language	English
Pages (from-to)	409-415
Number of pages	7
Journal	European Journal of Endocrinology
Volume	173
Issue number	3
DOIs	https://doi.org/10.1530/EJE-15-0115
Publication status	Published - Sep 1 2015

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Medicine(all)

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10.1530/EJE-15-0115

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Elevated heart rate predicts β cell function in non-diabetic individuals : The RISC cohort. / Bonnet, Fabrice; Empana, Jean Philippe; Natali, Andrea; Monti, Lucilla; Golay, Alain; Lalic, Katarina; Dekker, Jacqueline; Mari, Andrea; Balkau, Beverley.

In: European Journal of Endocrinology, Vol. 173, No. 3, 01.09.2015, p. 409-415.

Research output: Contribution to journal › Article › peer-review

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AU - Bonnet, Fabrice

AU - Empana, Jean Philippe

AU - Natali, Andrea

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AU - Golay, Alain

AU - Lalic, Katarina

AU - Dekker, Jacqueline

AU - Mari, Andrea

AU - Balkau, Beverley

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Elevated heart rate predicts β cell function in non-diabetic individuals: The RISC cohort

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