Elevated heart rate predicts β cell function in non-diabetic individuals: The RISC cohort

Fabrice Bonnet, Jean Philippe Empana, Andrea Natali, Lucilla Monti, Alain Golay, Katarina Lalic, Jacqueline Dekker, Andrea Mari, Beverley Balkau

Research output: Contribution to journalArticlepeer-review

Abstract

Context: Elevated heart rate has been associated with insulin resistance and incident type 2 diabetes but its relationship with β-cell function is not known. Our aim was to investigate whether baseline heart rate is associated with β-cell function and hyperglycaemia. Methods: We used the prospective RISC cohort with 1005 non-diabetic individuals who had an oral glucose tolerance test (OGTT) at baseline and after 3 years. Impaired glucose regulation was defined as a fasting plasma glucose ≥6.1 mmol/l or a 2-h plasma glucose ≥7.8 mmol/l. Insulin sensitivity was assessed by the OGIS index and insulin secretion and b-cell glucose sensitivity at both baseline and 3 years. Results: Baseline heart rate was positively related to both fasting (P

Original languageEnglish
Pages (from-to)409-415
Number of pages7
JournalEuropean Journal of Endocrinology
Volume173
Issue number3
DOIs
Publication statusPublished - Sep 1 2015

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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