Elevated levels of interleukin-6 in unstable angina

L. M. Biasucci, A. Vitelli, G. Liuzzo, S. Altamura, G. Caligiuri, C. Monaco, A. G. Rebuzzi, G. Ciliberto, A. Maseri

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Elevated plasma levels of C-reactive protein have been found in the majority of patients with unstable angina. The evidence of elevated levels of acute phase proteins in unstable angina is in line with a growing body of evidence that suggests that inflammation plays a role in this syndrome and is an indirect sign of increased production of interleukin-6, which is the major determinant of acute-phase-protein production by the liver. However, in unstable angina, there is no direct proof of the role played by interleukin-6. Methods and Results: We measured levels of interleukin-6 in 38 patients with unstable angina at the time of their admission to the coronary care unit and in 29 patients with stable angina. In the same groups of patients, we also measured C-reactive protein. Interleukin-6 (undetectable, ie,

Original languageEnglish
Pages (from-to)874-877
Number of pages4
JournalCirculation
Volume94
Issue number5
Publication statusPublished - 1996

Keywords

  • angina
  • interleukins
  • pathophysiology
  • prognosis
  • proteins

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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