Elevated levels of tumor necrosis factor-α in zairian neonate plasmas: Implications for perinatal infection with the human immunodeficiency virus

Christopher C. Brown, Guido Poli, Ndongala Lubaki, Michael St. Louis, Farzin Davachi, Luwy Musey, Tarande Manzila, Andrea Kovacs, Thomas C. Quinn, Anthony S. Fauci

Research output: Contribution to journalArticle

Abstract

Plasma levels of tumor necrosis factor-α (TNFα) and the ability of plasmas to induce HIV expression in chronically infected cell lines were measured in samples from adults, cord blood, and neonates from Zaire and North America. Plasma levels of TNFα were higher in Zairian neonates born to HIV-negative and -positive mothers than in uninfected Zairian adults (612 vs. 128 vs. 8 pg/mL, P

Original languageEnglish
Pages (from-to)975-980
Number of pages6
JournalJournal of Infectious Diseases
Volume169
Issue number5
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology
  • Public Health, Environmental and Occupational Health

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