Elevated maternal levels of the long pentraxin 3 (PTX3) in preeclampsia and intrauterine growth restriction

Irene Cetin, Veronica Cozzi, Fabio Pasqualini, Manuela Nebuloni, Cecilia Garlanda, Luca Vago, Giorgio Pardi, Alberto Mantovani

Research output: Contribution to journalArticlepeer-review


Objective: The prototypic long pentraxin pentraxin 3 is a new candidate marker for inflammatory conditions reflecting the involvement of the vascular bed. Endothelial dysfunction is a prominent feature of preeclampsia as a result of excessive maternal systemic inflammation. We investigated pentraxin 3 levels in preeclampsia and intrauterine growth restriction, pregnancy conditions related to altered placentation. Study design: We cross-sectionally studied nonpregnant women (n = 20); normal pregnancies in the first (n = 8), second (n = 10), and third (n = 26) trimester of pregnancy; 20 pregnancies complicated by preeclampsia; and 16 pregnancies complicated by intrauterine growth restriction. Maternal plasma samples were analyzed and pentraxin 3 determined by enzyme-linked immunosorbent assay. Pattern and site of placental expression of pentraxin 3 were studied by immunohistochemistry. Results: In normal pregnancies pentraxin 3 concentrations were significantly higher than nonpregnant women and did not change among the 3 trimesters. Significantly higher levels of pentraxin 3 were found in preeclampsia (median values 13.8 versus 2.2 ng/mL; P <.001), compared with normal pregnancies. Intrauterine growth restriction pregnancies showed intermediate levels between normal and preeclamptic patients, but this difference was not significant, compared with normal pregnancies (median values 3.9 versus 2.2 ng/mL). No significant difference of pentraxin 3 levels was found between mild and severe preeclampsia. Conclusion: Elevated maternal plasma levels of pentraxin 3 in preeclamptic versus normal pregnancies could represent a marker of altered endothelial function, typical of preeclampsia.

Original languageEnglish
Pages (from-to)1347-1353
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Issue number5
Publication statusPublished - May 2006


  • Endothelial dysfunction
  • Intrauterine growth restriction
  • Pentraxins
  • Preeclampsia
  • PTX3

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology


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