Elevated peripheral leukocyte counts in acute cervical artery dissection

C. Grond-Ginsbach, A. Giossi, S. S. Aksay, S. T. Engelter, P. A. Lyrer, T. M. Metso, A. J. Metso, T. Tatlisumak, S. Debette, D. Leys, V. Thijs, A. Bersano, S. Abboud, M. Kloss, C. Lichy, A. Grau, A. Pezzini, E. Touzé, Shérine Abboud, Massimo PandolfoVincent Thijs, Tiina Metso, Antti Metso, Turgut Tatlisumak, Marie Bodenant, Stéphanie Debette, Didier Leys, Paul Ossou, Fabien Louillet, Jean Louis Mas, Emmanuel Touzé, Sara Leder, Anne Léger, Sandrine Deltour, Sophie Crozier, Isabelle Méresse, Yves Samson, Sandrine Canaple, Olivier Godefroy, Chantal Lamy, Yannick Béjot, Maurice Giroud, Pierre Decavel, Elizabeth Medeiros, Paola Montiel, Thierry Moulin, Fabrice Vuillier, Philippe Amouyel, Jean Dallongeville, Grond-Ginsbach Caspar Grond-Ginsbach, Manja Kloss, Christoph Lichy, Tina Wiest, Inge Werner, Marie Luise Arnold, Michael Dos Santos, Armin Grau, Martin Dichgans, Ingrid Hausser, Tobias Brandt, Constanze Thomas-Feles, Ralf Weber, Elisabetta Del Zotto, Alessia Giossi, Irene Volonghi, Alessandro Padovani, Alessandro Pezzini, Valeria Caso, Anna Bersano, Silvia Lanfranconi, Pierluigi Baron, Simone Beretta, Carlo Ferrarese, Maria Sessa, Giacomo Giacolone, Stefano Paolucci, Stefan Engelter, Felix Fluri, Florian Hatz, Dominique Gisler, Annet Tiemessen, Margareth Amort, Philippe Lyrer, Hugh Markus, Ayse Altintas, Juan Jose Martin

Research output: Contribution to journalArticle

Abstract

Background and purpose: It has been suggested that inflammation may play a role in the development of cervical artery dissection (CeAD), but evidence remains scarce. Methods: A total of 172 patients were included with acute (<24 h) CeAD and 348 patients with acute ischaemic stroke (IS) of other (non-CeAD) causes from the Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) study, and 223 age- and sex-matched healthy control subjects. White blood cell (WBC) counts collected at admission were compared across the three groups. Results: Compared with healthy control subjects, CeAD patients and non-CeAD stroke patients had higher WBC counts (P <0.001). Patients with CeAD had higher WBC counts and were more likely to have WBC > 10 000/μl than non-CeAD stroke patients (38.4% vs. 23.0%, P <0.001) and healthy controls (38.4% vs. 8.5%, P <0.001). WBC counts were higher in CeAD (9.4 ± 3.3) than in IS of other causes (large artery atherosclerosis, 8.7 ± 2.3; cardioembolism, 8.2 ± 2.8; small vessel disease, 8.4 ± 2.4; undetermined cause, 8.8 ± 3.1; P = 0.022). After adjustment for age, sex, stroke severity and vascular risk factors in a multiple regression model, elevated WBC count remained associated with CeAD, as compared with non-CeAD stroke patients [odds ratio (OR) = 2.56; 95% CI 1.60-4.11; P <0.001) and healthy controls (OR = 6.27; 95% CI 3.39-11.61; P <0.001). Conclusions: Acute CeAD was associated with particularly high WBC counts. Leukocytosis may reflect a pre-existing inflammatory state, supporting the link between inflammation and CeAD.

Original languageEnglish
Pages (from-to)1405-1410
Number of pages6
JournalEuropean Journal of Neurology
Volume20
Issue number10
DOIs
Publication statusPublished - Oct 2013

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Keywords

  • Cervical artery dissection
  • Inflammation
  • Leukocytosis
  • White blood cell count

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Grond-Ginsbach, C., Giossi, A., Aksay, S. S., Engelter, S. T., Lyrer, P. A., Metso, T. M., Metso, A. J., Tatlisumak, T., Debette, S., Leys, D., Thijs, V., Bersano, A., Abboud, S., Kloss, M., Lichy, C., Grau, A., Pezzini, A., Touzé, E., Abboud, S., ... Martin, J. J. (2013). Elevated peripheral leukocyte counts in acute cervical artery dissection. European Journal of Neurology, 20(10), 1405-1410. https://doi.org/10.1111/ene.12201