Elevated plasma activator inhibitor 1 is not related to insulin resistance and to gene polymorphism in healthy centenarians

Maria Rosaria Rizzo, Emilia Ragno, Michelangela Barbieri, Domenico De Lucia, Daniela Manzella, Maria Rosaria Tagliamonte, Donatella Colaizzo, Maurizio Margaglione, Giuseppe Paolisso

Research output: Contribution to journalArticlepeer-review

Abstract

Previous studies demonstrated a relationship between the degree of insulin resistance and plasma plasminogen activator inhibitor type-1 (PAI-1) levels. We aim at investigating the relationship between the degree of insulin resistance and plasma PAI-1 levels in aged subjects (n = 83) and in healthy centenarians (n = 42). In all subjects the degree of insulin resistance was assessed by HOMA method. Our data demonstrated that healthy centenarians have higher plasma PAI-1 levels (73.1 ± 13.9 vs 23.7 ± 14.7 ng/ml, P <0.001) and lower degree of insulin resistance (1.4 ± 0.5 vs 3.3 ± 1.3, P <0.001) than aged subjects. In aged subjects plasma PAI-1 levels correlated with the degree of insulin resistance (r = 0.61, P <0.001), fasting plasma triglycerides (r = 0.74, P <0.001) and age (r = 0.33, P <0.001). All such associations were lost in centenarians. Plasma PAI-1 Ag levels were also similar in aged subjects and centenarians even after categorization for PAI gene polymorphism. In multivariate analysis, a model made by age, sex, body mass index, fasting plasma triglycerides, HOMA and PAI-1 gene explained 65 and 50% of plasma PAI-1 level variations in aged subjects and centenarians, respectively. Nevertheless, HOMA (P <0.001) was significantly and independently associated with plasma PAI-1 levels only in aged subjects. In conclusion, our data demonstrates that in healthy centenarians, plasma PAI-1 were not associated with the degree of insulin resistance as in aged subjects. Frequency of PAI-1 genotype does not provide an explanation for such differences between aged subjects and centenarians.

Original languageEnglish
Pages (from-to)385-390
Number of pages6
JournalAtherosclerosis
Volume160
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • Aged subjects
  • Centenarians
  • Insulin resistance
  • PAI-1 gene polymorphism
  • Plasma plasminogen activator inhibitor type-1 levels

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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