Previous studies demonstrated a relationship between the degree of insulin resistance and plasma plasminogen activator inhibitor type-1 (PAI-1) levels. We aim at investigating the relationship between the degree of insulin resistance and plasma PAI-1 levels in aged subjects (n = 83) and in healthy centenarians (n = 42). In all subjects the degree of insulin resistance was assessed by HOMA method. Our data demonstrated that healthy centenarians have higher plasma PAI-1 levels (73.1 ± 13.9 vs 23.7 ± 14.7 ng/ml, P <0.001) and lower degree of insulin resistance (1.4 ± 0.5 vs 3.3 ± 1.3, P <0.001) than aged subjects. In aged subjects plasma PAI-1 levels correlated with the degree of insulin resistance (r = 0.61, P <0.001), fasting plasma triglycerides (r = 0.74, P <0.001) and age (r = 0.33, P <0.001). All such associations were lost in centenarians. Plasma PAI-1 Ag levels were also similar in aged subjects and centenarians even after categorization for PAI gene polymorphism. In multivariate analysis, a model made by age, sex, body mass index, fasting plasma triglycerides, HOMA and PAI-1 gene explained 65 and 50% of plasma PAI-1 level variations in aged subjects and centenarians, respectively. Nevertheless, HOMA (P <0.001) was significantly and independently associated with plasma PAI-1 levels only in aged subjects. In conclusion, our data demonstrates that in healthy centenarians, plasma PAI-1 were not associated with the degree of insulin resistance as in aged subjects. Frequency of PAI-1 genotype does not provide an explanation for such differences between aged subjects and centenarians.
- Aged subjects
- Insulin resistance
- PAI-1 gene polymorphism
- Plasma plasminogen activator inhibitor type-1 levels
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine