Elevated serum alpha-fetoprotein in Wilms tumor may follow the same pattern of other fetal neoplasms after treatment: Evidence from three cases

A. Crocoli, S. Madafferi, A. Jenkner, A. Zaccara, A. Inserra

Research output: Contribution to journalArticle

Abstract

Alpha-fetoprotein (AFP) is a common tumoral marker in pediatric neoplasms; increased serum levels are usually encountered in tumors arising from tissues producing AFP during fetal life. However, elevation of such protein is rarely found in patients with Wilms tumor (WT). Three patients with WT and elevated serum AFP were studied over the course of the disease. One patient had left WT with invasion of aorto-caval lymph nodes and lung metastases. The second patient was referred to our center for abdominal recurrence of bilateral WT whereas the third showed right WT with inferior vena cava thrombosis. AFP levels demonstrated a trend parallel to decrease/increase of tumor size, with further elevation in patients with metastases. Elevated AFP serum levels in patients with WT could be related to peculiar histological features and serial dosage might be a useful diagnostic and prognostic test.

Original languageEnglish
Pages (from-to)499-502
Number of pages4
JournalPediatric Surgery International
Volume24
Issue number4
DOIs
Publication statusPublished - Apr 2008

Keywords

  • Alpha-fetoprotein
  • Children
  • Serum levels
  • Wilms tumor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

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