Elevated serum levels of osteopontin in HCV-associated lymphoproliferative disorders

Massimo Libra, Manuela Indelicato, Valli De Re, Anna Linda Zignego, Annalisa Chiocchetti, Grazia Malaponte, Umberto Dianzani, Ferdinando Nicoletti, Franca Stivala, James A. McCubrey, Maria C. Mazzarino

Research output: Contribution to journalArticlepeer-review


Hepatitis C virus (HCV) infection is associated with chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Recent evidences have also suggested that HCV infection contributes to development of autoimmune disorders and B-cell nonHodgkin's lymphoma (NHL). Mechanisms by which HCV infection promotes B-cell NHL development remain unclear. Increased serum osteopontin (OPN) levels have been associated with several autoimmune diseases as well as a variety of cancers. However, the association between OPN and B-cell NHL or HCV-associated B-cell proliferation has not previously been reported. In the present study, we determined whether serum OPN differences were associated with HCV infection, type II mixed cryglobulinemia (MC) syndrome and B-cell NHL. Serum OPN levels were measured by capture enzyme-linked immunosorbent assay. Our results show that high serum OPN levels are associated with B-cell NHL and HCV infection. Interestingly, highest serum OPN concentrations were found among HCV-infected patients with concomitant type II MC syndrome with and without B-cell NHL. These data indicate that OPN is involved in the lymphomagenesis, especially, in the context of HCV infection and autoimmune diseases.

Original languageEnglish
Pages (from-to)1192-1194
Number of pages3
JournalCancer Biology and Therapy
Issue number11
Publication statusPublished - Nov 2005


  • HCV
  • NHL
  • Ostepontin
  • Type II mixed cryoglobulinemia syndrome

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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