Elevated serum progesterone on the day of HCG administration in IVF is associated with a higher pregnancy rate in polycystic ovary syndrome

Nicola Doldi, Elena Marsiglio, Alessandro Destefani, Alessandra Gessi, Giampiero Merati, Augusto Ferrari

Research output: Contribution to journalArticlepeer-review

Abstract

Our study compared 84 patients with polycystic ovary syndrome (PCOS) with 84 control patients who had normal ovaries and who were matched for the main determinants of success in in-vitro fertilization (IVF) and embryo transfer. Serum concentrations of oestradiol and progesterone on the day of human chorionic gonadotrophin (HCG) injection were significantly higher in PCOS than in normal patients (oestradiol 2016 ± 1.8 pg/ml versus 1456 ± 40.9 pg/ml, P <0.01; progesterone 1.6 ± 0.1 ng/ml versus 1.2 ± 0.1 ng/ml, P = 0.03). Furthermore despite oocytes from PCOS patients having a reduced fertilization rate compared with normal patients (61.8 ± 4.1% versus 73.5 ± 4.3%, P = 0.03), the differences in pregnancy rate (22.6 versus 19%) and miscarriage (31.5 versus 18.7%) were not statistically significant. In PCOS patients, a critical breakpoint was identified at serum progesterone concentrations of 1.2 ng/ml on the day of HCG injection. The PCOS patients with progesterone ≥ 1.2 ng/ml showed a higher pregnancy and miscarriage rate than PCOS patients with progesterone <1.2 ng/ml (26.6 versus 17.9%, P <0.01; and 41.7% versus 14.3%, P <0.01 respectively). These findings suggest that premature progesterone production does not have an adverse effect on pregnancy rate in PCOS, but on the contrary, may be a predictor for success in IVF/embryo transfer.

Original languageEnglish
Pages (from-to)601-605
Number of pages5
JournalHuman Reproduction
Volume14
Issue number3
Publication statusPublished - 1999

Keywords

  • In-vitro fertilization
  • Oestradiol
  • Polycystic ovary syndrome
  • Progesterone

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynaecology
  • Reproductive Medicine

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