Elevated serum transforming growth factor β1 levels in Epstein-Barr virus-associated diseases and their correlation with virus-specific immunoglobulin A (IgA) and IgM

Jingwu Xu; Ali Ahmad; James F. Jones; Riccardo Dolcetti; Emanuela Vaccher; Umapati Prasad; José Menezes

doi:10.1128/JVI.74.5.2443-2446.2000

Elevated serum transforming growth factor β1 levels in Epstein-Barr virus-associated diseases and their correlation with virus-specific immunoglobulin A (IgA) and IgM

Jingwu Xu, Ali Ahmad, James F. Jones, Riccardo Dolcetti, Emanuela Vaccher, Umapati Prasad, José Menezes

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

Transforming growth factor β (TGF-β) is an immunosuppressive cytokine which can induce immunoglobulin A (IgA) switch and Epstein-Barr virus (EBV) replication in latently infected cells. Here we report elevated serum levels of TGF-β in various EBV-associated diseases correlating positively with EBV- specific IgA titers and negatively with IgM titers, suggesting a role for this cytokine in the pathogenesis of these diseases.

Original language	English
Pages (from-to)	2443-2446
Number of pages	4
Journal	Journal of Virology
Volume	74
Issue number	5
DOIs	https://doi.org/10.1128/JVI.74.5.2443-2446.2000
Publication status	Published - 2000

ASJC Scopus subject areas

Immunology

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10.1128/JVI.74.5.2443-2446.2000

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Elevated serum transforming growth factor β1 levels in Epstein-Barr virus-associated diseases and their correlation with virus-specific immunoglobulin A (IgA) and IgM. / Xu, Jingwu; Ahmad, Ali; Jones, James F.; Dolcetti, Riccardo; Vaccher, Emanuela; Prasad, Umapati; Menezes, José.

In: Journal of Virology, Vol. 74, No. 5, 2000, p. 2443-2446.

Research output: Contribution to journal › Article › peer-review

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AU - Menezes, José

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Elevated serum transforming growth factor β1 levels in Epstein-Barr virus-associated diseases and their correlation with virus-specific immunoglobulin A (IgA) and IgM

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