Elevated serum transforming growth factor β1 levels in Epstein-Barr virus-associated diseases and their correlation with virus-specific immunoglobulin A (IgA) and IgM

Jingwu Xu, Ali Ahmad, James F. Jones, Riccardo Dolcetti, Emanuela Vaccher, Umapati Prasad, José Menezes

Research output: Contribution to journalArticlepeer-review

Abstract

Transforming growth factor β (TGF-β) is an immunosuppressive cytokine which can induce immunoglobulin A (IgA) switch and Epstein-Barr virus (EBV) replication in latently infected cells. Here we report elevated serum levels of TGF-β in various EBV-associated diseases correlating positively with EBV- specific IgA titers and negatively with IgM titers, suggesting a role for this cytokine in the pathogenesis of these diseases.

Original languageEnglish
Pages (from-to)2443-2446
Number of pages4
JournalJournal of Virology
Volume74
Issue number5
DOIs
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Immunology

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