Elevated soluble CD14 receptors and altered cytokines in chronic heart failure

Stefan D. Anker; Karl R. Egerer; Hans Dieter Volk; Wolfgang J. Kox; Philip A. Poole-Wilson; Andrew J S Coats

doi:10.1016/S0002-9149(97)00159-8

Elevated soluble CD14 receptors and altered cytokines in chronic heart failure

Stefan D. Anker, Karl R. Egerer, Hans Dieter Volk, Wolfgang J. Kox, Philip A. Poole-Wilson, Andrew J S Coats

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article

Abstract

We hypothesized that in patients with chronic heart failure mesenteric venous congestion leads to increased bowel permeability, bacterial translocation, and thereby endotoxin release; the increased endotoxin challenge then causes immune activation with increased soluble CD14 levels and tumor necrosis factor (TNF)-α production. Patients with high soluble CD14 levels (indicative of endotoxin-cell interaction) have markedly increased plasma levels of TNF-α, soluble TNF receptors 1 and 2, and intracellular adhesion molecule-1, supporting this hypothesis.

Original language	English
Pages (from-to)	1426-1428
Number of pages	3
Journal	The American Journal of Cardiology
Volume	79
Issue number	10
DOIs	https://doi.org/10.1016/S0002-9149(97)00159-8
Publication status	Published - May 15 1997

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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Anker, S. D., Egerer, K. R., Volk, H. D., Kox, W. J., Poole-Wilson, P. A., & Coats, A. J. S. (1997). Elevated soluble CD14 receptors and altered cytokines in chronic heart failure. The American Journal of Cardiology, 79(10), 1426-1428. https://doi.org/10.1016/S0002-9149(97)00159-8

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AU - Coats, Andrew J S

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