TY - JOUR
T1 - Elevated soluble CD14 receptors and altered cytokines in chronic heart failure
AU - Anker, Stefan D.
AU - Egerer, Karl R.
AU - Volk, Hans Dieter
AU - Kox, Wolfgang J.
AU - Poole-Wilson, Philip A.
AU - Coats, Andrew J S
PY - 1997/5/15
Y1 - 1997/5/15
N2 - We hypothesized that in patients with chronic heart failure mesenteric venous congestion leads to increased bowel permeability, bacterial translocation, and thereby endotoxin release; the increased endotoxin challenge then causes immune activation with increased soluble CD14 levels and tumor necrosis factor (TNF)-α production. Patients with high soluble CD14 levels (indicative of endotoxin-cell interaction) have markedly increased plasma levels of TNF-α, soluble TNF receptors 1 and 2, and intracellular adhesion molecule-1, supporting this hypothesis.
AB - We hypothesized that in patients with chronic heart failure mesenteric venous congestion leads to increased bowel permeability, bacterial translocation, and thereby endotoxin release; the increased endotoxin challenge then causes immune activation with increased soluble CD14 levels and tumor necrosis factor (TNF)-α production. Patients with high soluble CD14 levels (indicative of endotoxin-cell interaction) have markedly increased plasma levels of TNF-α, soluble TNF receptors 1 and 2, and intracellular adhesion molecule-1, supporting this hypothesis.
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U2 - 10.1016/S0002-9149(97)00159-8
DO - 10.1016/S0002-9149(97)00159-8
M3 - Article
C2 - 9165177
AN - SCOPUS:0030977889
VL - 79
SP - 1426
EP - 1428
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 10
ER -