Elevated soluble CD14 receptors and altered cytokines in chronic heart failure

Stefan D. Anker, Karl R. Egerer, Hans Dieter Volk, Wolfgang J. Kox, Philip A. Poole-Wilson, Andrew J S Coats

Research output: Contribution to journalArticlepeer-review

Abstract

We hypothesized that in patients with chronic heart failure mesenteric venous congestion leads to increased bowel permeability, bacterial translocation, and thereby endotoxin release; the increased endotoxin challenge then causes immune activation with increased soluble CD14 levels and tumor necrosis factor (TNF)-α production. Patients with high soluble CD14 levels (indicative of endotoxin-cell interaction) have markedly increased plasma levels of TNF-α, soluble TNF receptors 1 and 2, and intracellular adhesion molecule-1, supporting this hypothesis.

Original languageEnglish
Pages (from-to)1426-1428
Number of pages3
JournalThe American Journal of Cardiology
Volume79
Issue number10
DOIs
Publication statusPublished - May 15 1997

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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