Elevated soluble intercellular adhesion molecule 1 in the serum of patients with polymyalgia rheumatica: Influence of steroid treatment

P. Macchioni, L. Boiardi, R. Meliconi, C. Salvarani, M. G. Ugoccioni, F. Rossi, L. Pulsatelli, A. Facchini

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To determine the levels of serum soluble intercellular adhesion molecule:l (sICAM-1) in patients with polymyalgia rheumatica (PMR) and/or giant cell arteritis (GCA) prior and during steroid therapy. Methods: Sixteen patients with PMR and/or GCA had complete clinical and laboratory investigations at diagnosis before treatment and 9 patients were followed during 6 months of steroid therapy. Serum sICAM-1 levels were measured by ELISA. Results: Serum ICAM-1 levels were higher in the patient group compared to a control population. No Significant correlation was found between serum sICAM-1 levels and other indices of disease activity. After steroid administration, a dramatic fall in serum sICAM-1 levels was observed at the end of the first week and persisted until the end of the study period, paralleling clinical and laboratory disease remission. Conclusion: Serum sICAM-1 levels paralleled disease activity in PMR and/or GCA. Steroid treatment induced a rapid normalization of the serum sICAM-1 levels.

Original languageEnglish
Pages (from-to)1860-1864
Number of pages5
JournalJournal of Rheumatology
Volume21
Issue number10
Publication statusPublished - 1994

Keywords

  • PMR
  • sICAM-1
  • Steroids

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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