Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms

Gregorio Tersalvi; Marco Vicenzi; Davide Calabretta; Luigi Biasco; Giovanni Pedrazzini; Dario Winterton

doi:10.1016/j.cardfail.2020.04.009

Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms

Gregorio Tersalvi, Marco Vicenzi, Davide Calabretta, Luigi Biasco, Giovanni Pedrazzini, Dario Winterton

Research output: Contribution to journal › Review article

Abstract

Coronavirus disease 2019 (COVID-19) is a pandemic that has affected more than 1.8 million people worldwide, overwhelmed health care systems owing to the high proportion of critical presentations, and resulted in more than 100,000 deaths. Since the first data analyses in China, elevated cardiac troponin has been noted in a substantial proportion of patients, implicating myocardial injury as a possible pathogenic mechanism contributing to severe illness and mortality. Accordingly, high troponin levels are associated with increased mortality in patients with COVID-19. This brief review explores the available evidence regarding the association between COVID-19 and myocardial injury.

Original language	English
Journal	Journal of Cardiac Failure
DOIs	https://doi.org/10.1016/j.cardfail.2020.04.009
Publication status	Accepted/In press - Jan 1 2020

Keywords

Coronavirus
COVID-19
Myocardial injury
Myocarditis
SARS
Troponin

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.cardfail.2020.04.009

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Tersalvi, G., Vicenzi, M., Calabretta, D., Biasco, L., Pedrazzini, G., & Winterton, D. (Accepted/In press). Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms. Journal of Cardiac Failure. https://doi.org/10.1016/j.cardfail.2020.04.009

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abstract = "Coronavirus disease 2019 (COVID-19) is a pandemic that has affected more than 1.8 million people worldwide, overwhelmed health care systems owing to the high proportion of critical presentations, and resulted in more than 100,000 deaths. Since the first data analyses in China, elevated cardiac troponin has been noted in a substantial proportion of patients, implicating myocardial injury as a possible pathogenic mechanism contributing to severe illness and mortality. Accordingly, high troponin levels are associated with increased mortality in patients with COVID-19. This brief review explores the available evidence regarding the association between COVID-19 and myocardial injury.",

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AU - Pedrazzini, Giovanni

AU - Winterton, Dario

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