Abstract
The mechanisms of excess aldosterone secretion in primary aldosteronism (PA) remain poorly understood, although a role for circulating factors has been hypothesized for decades. Agonistic autoantibodies against type-1 angiotensin-II receptor (AT1AA) are detectable in malignant hypertension and preeclampsia and might play a role in PA. Moreover, if they were elevated in aldosterone- producing adenoma (APA) and not in idiopathic hyperaldosteronism (IHA), they might be useful for discriminating between these conditions. To test these hypotheses, we measured the titer of AT1AA in serum of 46 patients with PA (26 with APA, 20 with IHA), 62 with primary hypertension (PH), 13 preeclamptic women, and 45 healthy normotensive blood donors.We found that the AT1AA titer was higher (P
| Original language | English |
|---|---|
| Pages (from-to) | 526-533 |
| Number of pages | 8 |
| Journal | Hypertension |
| Volume | 61 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2013 |
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Keywords
- angiotensin-II
- antibodies
- AT1 receptor
- autoimmunity
- primary aldosteronism
ASJC Scopus subject areas
- Internal Medicine
Cite this
Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary aldosteronism as a result of aldosterone-producing adenoma. / Rossitto, Giacomo; Regolisti, Giuseppe; Rossi, Ermanno; Negro, Aurelio; Nicoli, Davide; Casali, Bruno; Toniato, Antonio; Caroccia, Brasilina; Seccia, Teresa Maria; Walther, Thomas; Rossi, Gian Paolo.
In: Hypertension, Vol. 61, No. 2, 02.2013, p. 526-533.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary aldosteronism as a result of aldosterone-producing adenoma
AU - Rossitto, Giacomo
AU - Regolisti, Giuseppe
AU - Rossi, Ermanno
AU - Negro, Aurelio
AU - Nicoli, Davide
AU - Casali, Bruno
AU - Toniato, Antonio
AU - Caroccia, Brasilina
AU - Seccia, Teresa Maria
AU - Walther, Thomas
AU - Rossi, Gian Paolo
PY - 2013/2
Y1 - 2013/2
N2 - The mechanisms of excess aldosterone secretion in primary aldosteronism (PA) remain poorly understood, although a role for circulating factors has been hypothesized for decades. Agonistic autoantibodies against type-1 angiotensin-II receptor (AT1AA) are detectable in malignant hypertension and preeclampsia and might play a role in PA. Moreover, if they were elevated in aldosterone- producing adenoma (APA) and not in idiopathic hyperaldosteronism (IHA), they might be useful for discriminating between these conditions. To test these hypotheses, we measured the titer of AT1AA in serum of 46 patients with PA (26 with APA, 20 with IHA), 62 with primary hypertension (PH), 13 preeclamptic women, and 45 healthy normotensive blood donors.We found that the AT1AA titer was higher (P
AB - The mechanisms of excess aldosterone secretion in primary aldosteronism (PA) remain poorly understood, although a role for circulating factors has been hypothesized for decades. Agonistic autoantibodies against type-1 angiotensin-II receptor (AT1AA) are detectable in malignant hypertension and preeclampsia and might play a role in PA. Moreover, if they were elevated in aldosterone- producing adenoma (APA) and not in idiopathic hyperaldosteronism (IHA), they might be useful for discriminating between these conditions. To test these hypotheses, we measured the titer of AT1AA in serum of 46 patients with PA (26 with APA, 20 with IHA), 62 with primary hypertension (PH), 13 preeclamptic women, and 45 healthy normotensive blood donors.We found that the AT1AA titer was higher (P
KW - angiotensin-II
KW - antibodies
KW - AT1 receptor
KW - autoimmunity
KW - primary aldosteronism
UR - http://www.scopus.com/inward/record.url?scp=84873060804&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873060804&partnerID=8YFLogxK
U2 - 10.1161/HYPERTENSIONAHA.112.202945
DO - 10.1161/HYPERTENSIONAHA.112.202945
M3 - Article
C2 - 23248149
AN - SCOPUS:84873060804
VL - 61
SP - 526
EP - 533
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 2
ER -