Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary aldosteronism as a result of aldosterone-producing adenoma

Giacomo Rossitto, Giuseppe Regolisti, Ermanno Rossi, Aurelio Negro, Davide Nicoli, Bruno Casali, Antonio Toniato, Brasilina Caroccia, Teresa Maria Seccia, Thomas Walther, Gian Paolo Rossi

Research output: Contribution to journalArticlepeer-review

Abstract

The mechanisms of excess aldosterone secretion in primary aldosteronism (PA) remain poorly understood, although a role for circulating factors has been hypothesized for decades. Agonistic autoantibodies against type-1 angiotensin-II receptor (AT1AA) are detectable in malignant hypertension and preeclampsia and might play a role in PA. Moreover, if they were elevated in aldosterone- producing adenoma (APA) and not in idiopathic hyperaldosteronism (IHA), they might be useful for discriminating between these conditions. To test these hypotheses, we measured the titer of AT1AA in serum of 46 patients with PA (26 with APA, 20 with IHA), 62 with primary hypertension (PH), 13 preeclamptic women, and 45 healthy normotensive blood donors.We found that the AT1AA titer was higher (P

Original languageEnglish
Pages (from-to)526-533
Number of pages8
JournalHypertension
Volume61
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • angiotensin-II
  • antibodies
  • AT1 receptor
  • autoimmunity
  • primary aldosteronism

ASJC Scopus subject areas

  • Internal Medicine

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