Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary aldosteronism as a result of aldosterone-producing adenoma

Giacomo Rossitto; Giuseppe Regolisti; Ermanno Rossi; Aurelio Negro; Davide Nicoli; Bruno Casali; Antonio Toniato; Brasilina Caroccia; Teresa Maria Seccia; Thomas Walther; Gian Paolo Rossi

doi:10.1161/HYPERTENSIONAHA.112.202945

Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary aldosteronism as a result of aldosterone-producing adenoma

Giacomo Rossitto, Giuseppe Regolisti, Ermanno Rossi, Aurelio Negro, Davide Nicoli, Bruno Casali, Antonio Toniato, Brasilina Caroccia, Teresa Maria Seccia, Thomas Walther, Gian Paolo Rossi

Arcispedale Santa Maria Nuova

Research output: Contribution to journal › Article › peer-review

Abstract

The mechanisms of excess aldosterone secretion in primary aldosteronism (PA) remain poorly understood, although a role for circulating factors has been hypothesized for decades. Agonistic autoantibodies against type-1 angiotensin-II receptor (AT1AA) are detectable in malignant hypertension and preeclampsia and might play a role in PA. Moreover, if they were elevated in aldosterone- producing adenoma (APA) and not in idiopathic hyperaldosteronism (IHA), they might be useful for discriminating between these conditions. To test these hypotheses, we measured the titer of AT1AA in serum of 46 patients with PA (26 with APA, 20 with IHA), 62 with primary hypertension (PH), 13 preeclamptic women, and 45 healthy normotensive blood donors.We found that the AT1AA titer was higher (P

Original language	English
Pages (from-to)	526-533
Number of pages	8
Journal	Hypertension
Volume	61
Issue number	2
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.112.202945
Publication status	Published - Feb 2013

Keywords

angiotensin-II
antibodies
AT1 receptor
autoimmunity
primary aldosteronism

ASJC Scopus subject areas

Internal Medicine

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10.1161/HYPERTENSIONAHA.112.202945

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Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary aldosteronism as a result of aldosterone-producing adenoma. / Rossitto, Giacomo; Regolisti, Giuseppe; Rossi, Ermanno; Negro, Aurelio; Nicoli, Davide; Casali, Bruno; Toniato, Antonio; Caroccia, Brasilina; Seccia, Teresa Maria; Walther, Thomas; Rossi, Gian Paolo.

In: Hypertension, Vol. 61, No. 2, 02.2013, p. 526-533.

Research output: Contribution to journal › Article › peer-review

Rossitto, Giacomo ; Regolisti, Giuseppe ; Rossi, Ermanno ; Negro, Aurelio ; Nicoli, Davide ; Casali, Bruno ; Toniato, Antonio ; Caroccia, Brasilina ; Seccia, Teresa Maria ; Walther, Thomas ; Rossi, Gian Paolo. / Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary aldosteronism as a result of aldosterone-producing adenoma. In: Hypertension. 2013 ; Vol. 61, No. 2. pp. 526-533.

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abstract = "The mechanisms of excess aldosterone secretion in primary aldosteronism (PA) remain poorly understood, although a role for circulating factors has been hypothesized for decades. Agonistic autoantibodies against type-1 angiotensin-II receptor (AT1AA) are detectable in malignant hypertension and preeclampsia and might play a role in PA. Moreover, if they were elevated in aldosterone- producing adenoma (APA) and not in idiopathic hyperaldosteronism (IHA), they might be useful for discriminating between these conditions. To test these hypotheses, we measured the titer of AT1AA in serum of 46 patients with PA (26 with APA, 20 with IHA), 62 with primary hypertension (PH), 13 preeclamptic women, and 45 healthy normotensive blood donors.We found that the AT1AA titer was higher (P",

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author = "Giacomo Rossitto and Giuseppe Regolisti and Ermanno Rossi and Aurelio Negro and Davide Nicoli and Bruno Casali and Antonio Toniato and Brasilina Caroccia and Seccia, {Teresa Maria} and Thomas Walther and Rossi, {Gian Paolo}",

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AU - Nicoli, Davide

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