Abstract
The mechanisms of excess aldosterone secretion in primary aldosteronism (PA) remain poorly understood, although a role for circulating factors has been hypothesized for decades. Agonistic autoantibodies against type-1 angiotensin-II receptor (AT1AA) are detectable in malignant hypertension and preeclampsia and might play a role in PA. Moreover, if they were elevated in aldosterone- producing adenoma (APA) and not in idiopathic hyperaldosteronism (IHA), they might be useful for discriminating between these conditions. To test these hypotheses, we measured the titer of AT1AA in serum of 46 patients with PA (26 with APA, 20 with IHA), 62 with primary hypertension (PH), 13 preeclamptic women, and 45 healthy normotensive blood donors.We found that the AT1AA titer was higher (P
Original language | English |
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Pages (from-to) | 526-533 |
Number of pages | 8 |
Journal | Hypertension |
Volume | 61 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2013 |
Keywords
- angiotensin-II
- antibodies
- AT1 receptor
- autoimmunity
- primary aldosteronism
ASJC Scopus subject areas
- Internal Medicine