Elevation of plasma levels of the long pentraxin 3 precedes preeclampsia in pregnant patients with type 1 diabetes

Maria Teresa Castiglioni, Marina Scavini, Rubina Cavallin, Federica Pasi, Susanna Rosa, Maria Grazia Sabbadini, Patrizia Rovere-Querini

Research output: Contribution to journalArticle

Abstract

Pregnancy complications, such as preeclampsia (PEc), have an increased incidence among patients with type 1 diabetes (T1DM), possibly because of maternal vascular involvement. The prototypic long pentraxin, pentraxin 3 (PTX3) is an acute phase reactant critically associated with vascular injury. PTX3 concentrations selectively increase in pregnant women with PEc. Here, we measured PTX3 levels in 37 consecutive pregnant patients with T1DM. Compared with PTX3 levels in healthy pregnant women at identical gestational ages, PTX3 was significantly elevated in pregnant women with diabetes. Patients with pre-existing nephropathy, a well-characterized microvascular complication of diabetes, have even higher PTX3 concentrations and worse maternal and fetal outcomes. Six/thirty-four diabetic non-nephropatic patients developed PEc: PTX3 levels rose abruptly weeks before PEc manifested (p 0.0375). PTX3 may represent a valuable marker for early detection and prediction of PEc in patients with T1DM.

Original languageEnglish
Pages (from-to)296-298
Number of pages3
JournalAutoimmunity
Volume42
Issue number4
DOIs
Publication statusPublished - 2009

Fingerprint

Pre-Eclampsia
Type 1 Diabetes Mellitus
Pregnant Women
Mothers
Pregnancy Complications
PTX3 protein
Acute-Phase Proteins
Vascular System Injuries
Diabetes Complications
Gestational Age
Blood Vessels
Incidence

Keywords

  • Innate immunity
  • Preeclampsia
  • Pregnancy
  • PTX3
  • Type 1 diabetes
  • Vessel inflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Elevation of plasma levels of the long pentraxin 3 precedes preeclampsia in pregnant patients with type 1 diabetes. / Castiglioni, Maria Teresa; Scavini, Marina; Cavallin, Rubina; Pasi, Federica; Rosa, Susanna; Sabbadini, Maria Grazia; Rovere-Querini, Patrizia.

In: Autoimmunity, Vol. 42, No. 4, 2009, p. 296-298.

Research output: Contribution to journalArticle

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