TY - JOUR
T1 - Elevation of plasma levels of the long pentraxin 3 precedes preeclampsia in pregnant patients with type 1 diabetes
AU - Castiglioni, Maria Teresa
AU - Scavini, Marina
AU - Cavallin, Rubina
AU - Pasi, Federica
AU - Rosa, Susanna
AU - Sabbadini, Maria Grazia
AU - Rovere-Querini, Patrizia
PY - 2009
Y1 - 2009
N2 - Pregnancy complications, such as preeclampsia (PEc), have an increased incidence among patients with type 1 diabetes (T1DM), possibly because of maternal vascular involvement. The prototypic long pentraxin, pentraxin 3 (PTX3) is an acute phase reactant critically associated with vascular injury. PTX3 concentrations selectively increase in pregnant women with PEc. Here, we measured PTX3 levels in 37 consecutive pregnant patients with T1DM. Compared with PTX3 levels in healthy pregnant women at identical gestational ages, PTX3 was significantly elevated in pregnant women with diabetes. Patients with pre-existing nephropathy, a well-characterized microvascular complication of diabetes, have even higher PTX3 concentrations and worse maternal and fetal outcomes. Six/thirty-four diabetic non-nephropatic patients developed PEc: PTX3 levels rose abruptly weeks before PEc manifested (p 0.0375). PTX3 may represent a valuable marker for early detection and prediction of PEc in patients with T1DM.
AB - Pregnancy complications, such as preeclampsia (PEc), have an increased incidence among patients with type 1 diabetes (T1DM), possibly because of maternal vascular involvement. The prototypic long pentraxin, pentraxin 3 (PTX3) is an acute phase reactant critically associated with vascular injury. PTX3 concentrations selectively increase in pregnant women with PEc. Here, we measured PTX3 levels in 37 consecutive pregnant patients with T1DM. Compared with PTX3 levels in healthy pregnant women at identical gestational ages, PTX3 was significantly elevated in pregnant women with diabetes. Patients with pre-existing nephropathy, a well-characterized microvascular complication of diabetes, have even higher PTX3 concentrations and worse maternal and fetal outcomes. Six/thirty-four diabetic non-nephropatic patients developed PEc: PTX3 levels rose abruptly weeks before PEc manifested (p 0.0375). PTX3 may represent a valuable marker for early detection and prediction of PEc in patients with T1DM.
KW - Innate immunity
KW - Preeclampsia
KW - Pregnancy
KW - PTX3
KW - Type 1 diabetes
KW - Vessel inflammation
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U2 - 10.1080/08916930902831464
DO - 10.1080/08916930902831464
M3 - Article
C2 - 19811281
AN - SCOPUS:70749109856
VL - 42
SP - 296
EP - 298
JO - Autoimmunity
JF - Autoimmunity
SN - 0891-6934
IS - 4
ER -