Elevations of inflammatory markers PTX3 and sST2 after resuscitation from cardiac arrest are associated with multiple organ dysfunction syndrome and early death

Giuseppe Ristagno, Tero Varpula, Serge Masson, Marta Greco, Barbara Bottazzi, Valentina Milani, Aneta Aleksova, Gianfranco Sinagra, Roberto Assandri, Marjaana Tiainen, Jukka Vaahersalo, Jouni Kurola, Simona Barlera, Alessandro Montanelli, Roberto Latini, Ville Pettilä, Stepani Bendel, Markus B. Skrifvars

Research output: Contribution to journalArticle

Abstract

Background: A systemic inflammatory response is observed after cardiopulmonary resuscitation. We investigated two novel inflammatory markers, pentraxin 3 (PTX3) and soluble suppression of tumorigenicity 2 (sST2), in comparison with the classic high-sensitivity C-reactive protein (hsCRP), for prediction of early multiple organ dysfunction syndrome (MODS), early death, and long-term outcome after out-of-hospital cardiac arrest. Methods: PTX3, sST2, and hsCRP were assayed at ICU admission and 48 h later in 278 patients. MODS was defined as the 24 h non-neurological Sequential Organ Failure Assessment (SOFA) score ≥12. Intensive care unit (ICU) death and 12-month Cerebral Performance Category (CPC) were evaluated. Results: In total, 82% of patients survived to ICU discharge and 48% had favorable neurological outcome at 1 year (CPC 1 or 2). At ICU admission, median plasma levels of hsCRP (2.8 mg/L) were normal, while levels of PTX3 (19.1 ng/mL) and sST2 (117 ng/mL) were markedly elevated. PTX3 and sST2 were higher in patients who developed MODS (p

Original languageEnglish
Pages (from-to)1847-1857
Number of pages11
JournalClinical Chemistry and Laboratory Medicine
Volume53
Issue number11
DOIs
Publication statusPublished - Oct 1 2015

Keywords

  • cardiac arrest
  • pentraxin 3 (PTX3)
  • ST2

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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    Ristagno, G., Varpula, T., Masson, S., Greco, M., Bottazzi, B., Milani, V., Aleksova, A., Sinagra, G., Assandri, R., Tiainen, M., Vaahersalo, J., Kurola, J., Barlera, S., Montanelli, A., Latini, R., Pettilä, V., Bendel, S., & Skrifvars, M. B. (2015). Elevations of inflammatory markers PTX3 and sST2 after resuscitation from cardiac arrest are associated with multiple organ dysfunction syndrome and early death. Clinical Chemistry and Laboratory Medicine, 53(11), 1847-1857. https://doi.org/10.1515/cclm-2014-1271