Abstract
Eleven balanced X-autosome translocations associated with premature ovarian failure (POF) were mapped to a YAC contig spanning most of Xq21 and constructed between the DXS223 and DXS1171 loci. The contig corresponds to a genomic region of about 15 Mb and contains the whole X-Y homologous region. The most proximal and most distal breakpoints associated with POF were mapped 15 Mb apart. The remaining breakpoints were localized along this large region, in the X-specific and in the X-Y homologous region. Four of the YACs contained two breakpoints in the same or in flanking STS intervals. Our results confirm the cytological findings and suggest that a minimum number of eight different genes in Xq21 may be involved with ovary development. Interruption of such loci could be the cause of POF.
| Original language | English |
|---|---|
| Pages (from-to) | 123-131 |
| Number of pages | 9 |
| Journal | Genomics |
| Volume | 40 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 15 1997 |
Fingerprint
ASJC Scopus subject areas
- Genetics
Cite this
Eleven X chromosome breakpoints associated with premature ovarian failure (POF) map to a 15-mb YAC contig spanning Xq21. / Sala, Cinzia; Arrigo, Giulia; Torri, Giovanna; Martinazzi, Francesco; Riva, Paola; Larizza, Lidia; Philippe, Christophe; Jonveaux, Philippe; Sloan, Frederique; Labella, Tullio; Toniolo, Daniela.
In: Genomics, Vol. 40, No. 1, 15.02.1997, p. 123-131.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Eleven X chromosome breakpoints associated with premature ovarian failure (POF) map to a 15-mb YAC contig spanning Xq21
AU - Sala, Cinzia
AU - Arrigo, Giulia
AU - Torri, Giovanna
AU - Martinazzi, Francesco
AU - Riva, Paola
AU - Larizza, Lidia
AU - Philippe, Christophe
AU - Jonveaux, Philippe
AU - Sloan, Frederique
AU - Labella, Tullio
AU - Toniolo, Daniela
PY - 1997/2/15
Y1 - 1997/2/15
N2 - Eleven balanced X-autosome translocations associated with premature ovarian failure (POF) were mapped to a YAC contig spanning most of Xq21 and constructed between the DXS223 and DXS1171 loci. The contig corresponds to a genomic region of about 15 Mb and contains the whole X-Y homologous region. The most proximal and most distal breakpoints associated with POF were mapped 15 Mb apart. The remaining breakpoints were localized along this large region, in the X-specific and in the X-Y homologous region. Four of the YACs contained two breakpoints in the same or in flanking STS intervals. Our results confirm the cytological findings and suggest that a minimum number of eight different genes in Xq21 may be involved with ovary development. Interruption of such loci could be the cause of POF.
AB - Eleven balanced X-autosome translocations associated with premature ovarian failure (POF) were mapped to a YAC contig spanning most of Xq21 and constructed between the DXS223 and DXS1171 loci. The contig corresponds to a genomic region of about 15 Mb and contains the whole X-Y homologous region. The most proximal and most distal breakpoints associated with POF were mapped 15 Mb apart. The remaining breakpoints were localized along this large region, in the X-specific and in the X-Y homologous region. Four of the YACs contained two breakpoints in the same or in flanking STS intervals. Our results confirm the cytological findings and suggest that a minimum number of eight different genes in Xq21 may be involved with ovary development. Interruption of such loci could be the cause of POF.
UR - http://www.scopus.com/inward/record.url?scp=0031568876&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031568876&partnerID=8YFLogxK
U2 - 10.1006/geno.1996.4542
DO - 10.1006/geno.1996.4542
M3 - Article
C2 - 9070928
AN - SCOPUS:0031568876
VL - 40
SP - 123
EP - 131
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 1
ER -