Elicitation of immune responsiveness against antigenic challenge in age-related diseases: Effects of red wine polyphenols

T. Magrone, A. Tafaro, F. Jirillo, L. Amati, E. Jirillo, V. Covelli

Research output: Contribution to journalArticle

Abstract

Polyphenols contained in red wine possess a broad array of properties which seem to be beneficial to human and animal health. We have investigated the ability of red wine polyphenols to promote the in vitro release of both proinflammatory and anti-inflammatory cytokines from human healthy mononuclear cells, as well as of immunoglobulins from B cells. Following red wine (Negroamaro) pretreatment of lymphomonocytes, results will show a production of regulatory Interleukin (IL)-12, proinflammatory (IL-1β and IL-6), and anti-inflammatory (IL-10) cytokines, as well as of IgA and IgG. The fine balance between inflammation and antiinflammation, as well as the role of humoral immune response either systemic or mucosal will be discussed as a consequence of red wine intake. Finally, since ageing is characterized by a decline of many immune functions, our results suggest that moderate use of red wine may be beneficial in age-related disorders where the host immune response is very often not effective against a variety of antigens.

Original languageEnglish
Pages (from-to)2749-2757
Number of pages9
JournalCurrent Pharmaceutical Design
Volume14
Issue number26
DOIs
Publication statusPublished - 2008

Fingerprint

Polyphenols
Wine
Anti-Inflammatory Agents
Cytokines
Immune System Diseases
Interleukin-12
Humoral Immunity
Interleukin-1
Interleukin-10
Immunoglobulin A
Interleukin-6
B-Lymphocytes
Immunoglobulin G
Inflammation
Antigens
Health

Keywords

  • Aging
  • Cytokines
  • Diet
  • Immune response
  • Immunoglobulins
  • Polyphenols
  • Red wine

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Elicitation of immune responsiveness against antigenic challenge in age-related diseases : Effects of red wine polyphenols. / Magrone, T.; Tafaro, A.; Jirillo, F.; Amati, L.; Jirillo, E.; Covelli, V.

In: Current Pharmaceutical Design, Vol. 14, No. 26, 2008, p. 2749-2757.

Research output: Contribution to journalArticle

Magrone, T. ; Tafaro, A. ; Jirillo, F. ; Amati, L. ; Jirillo, E. ; Covelli, V. / Elicitation of immune responsiveness against antigenic challenge in age-related diseases : Effects of red wine polyphenols. In: Current Pharmaceutical Design. 2008 ; Vol. 14, No. 26. pp. 2749-2757.
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