Abstract
Polyphenols contained in red wine possess a broad array of properties which seem to be beneficial to human and animal health. We have investigated the ability of red wine polyphenols to promote the in vitro release of both proinflammatory and anti-inflammatory cytokines from human healthy mononuclear cells, as well as of immunoglobulins from B cells. Following red wine (Negroamaro) pretreatment of lymphomonocytes, results will show a production of regulatory Interleukin (IL)-12, proinflammatory (IL-1β and IL-6), and anti-inflammatory (IL-10) cytokines, as well as of IgA and IgG. The fine balance between inflammation and antiinflammation, as well as the role of humoral immune response either systemic or mucosal will be discussed as a consequence of red wine intake. Finally, since ageing is characterized by a decline of many immune functions, our results suggest that moderate use of red wine may be beneficial in age-related disorders where the host immune response is very often not effective against a variety of antigens.
| Original language | English |
|---|---|
| Pages (from-to) | 2749-2757 |
| Number of pages | 9 |
| Journal | Current Pharmaceutical Design |
| Volume | 14 |
| Issue number | 26 |
| DOIs | |
| Publication status | Published - 2008 |
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Keywords
- Aging
- Cytokines
- Diet
- Immune response
- Immunoglobulins
- Polyphenols
- Red wine
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
Cite this
Elicitation of immune responsiveness against antigenic challenge in age-related diseases : Effects of red wine polyphenols. / Magrone, T.; Tafaro, A.; Jirillo, F.; Amati, L.; Jirillo, E.; Covelli, V.
In: Current Pharmaceutical Design, Vol. 14, No. 26, 2008, p. 2749-2757.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Elicitation of immune responsiveness against antigenic challenge in age-related diseases
T2 - Effects of red wine polyphenols
AU - Magrone, T.
AU - Tafaro, A.
AU - Jirillo, F.
AU - Amati, L.
AU - Jirillo, E.
AU - Covelli, V.
PY - 2008
Y1 - 2008
N2 - Polyphenols contained in red wine possess a broad array of properties which seem to be beneficial to human and animal health. We have investigated the ability of red wine polyphenols to promote the in vitro release of both proinflammatory and anti-inflammatory cytokines from human healthy mononuclear cells, as well as of immunoglobulins from B cells. Following red wine (Negroamaro) pretreatment of lymphomonocytes, results will show a production of regulatory Interleukin (IL)-12, proinflammatory (IL-1β and IL-6), and anti-inflammatory (IL-10) cytokines, as well as of IgA and IgG. The fine balance between inflammation and antiinflammation, as well as the role of humoral immune response either systemic or mucosal will be discussed as a consequence of red wine intake. Finally, since ageing is characterized by a decline of many immune functions, our results suggest that moderate use of red wine may be beneficial in age-related disorders where the host immune response is very often not effective against a variety of antigens.
AB - Polyphenols contained in red wine possess a broad array of properties which seem to be beneficial to human and animal health. We have investigated the ability of red wine polyphenols to promote the in vitro release of both proinflammatory and anti-inflammatory cytokines from human healthy mononuclear cells, as well as of immunoglobulins from B cells. Following red wine (Negroamaro) pretreatment of lymphomonocytes, results will show a production of regulatory Interleukin (IL)-12, proinflammatory (IL-1β and IL-6), and anti-inflammatory (IL-10) cytokines, as well as of IgA and IgG. The fine balance between inflammation and antiinflammation, as well as the role of humoral immune response either systemic or mucosal will be discussed as a consequence of red wine intake. Finally, since ageing is characterized by a decline of many immune functions, our results suggest that moderate use of red wine may be beneficial in age-related disorders where the host immune response is very often not effective against a variety of antigens.
KW - Aging
KW - Cytokines
KW - Diet
KW - Immune response
KW - Immunoglobulins
KW - Polyphenols
KW - Red wine
UR - http://www.scopus.com/inward/record.url?scp=57349180916&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57349180916&partnerID=8YFLogxK
U2 - 10.2174/138161208786264043
DO - 10.2174/138161208786264043
M3 - Article
C2 - 18991693
AN - SCOPUS:57349180916
VL - 14
SP - 2749
EP - 2757
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
SN - 1381-6128
IS - 26
ER -