ELISA reveals a difference in the structure of substantia nigra ferritin in Parkinson's disease and incidental Lewy body compared to control

Dariusz Koziorowski, Andrzej Friedman, Paolo Arosio, Paolo Santambrogio, Dorota Dziewulska

Research output: Contribution to journalArticle

Abstract

Iron released from ferritin may trigger oxidative stress leading to progressive neurodegeneration of substantia nigra resulting in Parkinson's disease (PD). Change in the structure of ferritin may allow an easier efflux of iron. We compared with the use of ELISA the structure of ferritin (concentrations of H and L ferritins) in substantia nigra (SN) in ten cases of PD, six of incidental Lewy body (ILB) cases and 20 controls. SN concentration of L ferritin in ILB (50.6±11.5 ng/mg) and in PD (52.5±26.0) was lower than in control (97.9±54.9). H ferritin in PD (534.2±223.1) was higher than in ILB (336.9±87.7) and control (374.8±169.3). The decrease of L ferritin in SN in PD and ILB may suggest that the whole process of neurodegeneration starts with a higher availability of free iron, which is released from the ferritin shell.

Original languageEnglish
Pages (from-to)214-218
Number of pages5
JournalParkinsonism and Related Disorders
Volume13
Issue number4
DOIs
Publication statusPublished - May 2007

Keywords

  • Ferritin structure
  • Incidental Lewy body
  • Parkinson's disease

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Neurology

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