Eltrombopag increases platelet numbers in thrombocytopenic patients with hcv infection and cirrhosis, allowing for effective antiviral therapy

Nezam H. Afdhal; Geoffrey M. Dusheiko; Edoardo G. Giannini; Pei Jer Chen; Kwang Hyub Han; Aftab Mohsin; Maribel Rodriguez-Torres; Sorin Rugina; Igor Bakulin; Eric Lawitz; Mitchell L. Shiffman; Ghias Un Nabi Tayyab; Fred Poordad; Yasser Mostafa Kamel; Andres Brainsky; James Geib; Sandra Y. Vasey; Rita Patwardhan; Fiona M. Campbell; Dickens Theodore

doi:10.1053/j.gastro.2013.10.012

Eltrombopag increases platelet numbers in thrombocytopenic patients with hcv infection and cirrhosis, allowing for effective antiviral therapy

Nezam H. Afdhal, Geoffrey M. Dusheiko, Edoardo G. Giannini, Pei Jer Chen, Kwang Hyub Han, Aftab Mohsin, Maribel Rodriguez-Torres, Sorin Rugina, Igor Bakulin, Eric Lawitz, Mitchell L. Shiffman, Ghias Un Nabi Tayyab, Fred Poordad, Yasser Mostafa Kamel, Andres Brainsky, James Geib, Sandra Y. Vasey, Rita Patwardhan, Fiona M. Campbell, Dickens Theodore

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Background & Aims Thrombocytopenia is common among patients with hepatitis C virus (HCV) infection and advanced fibrosis or cirrhosis, limiting initiation and dose of peginterferon-alfa (PEG) and ribavirin (RBV) therapy. The phase 3 randomized, controlled studies, Eltrombopag to Initiate and Maintain Interferon Antiviral Treatment to Benefit Subjects with Hepatitis C-Related Liver Disease (ENABLE)-1 and ENABLE-2, investigated the ability of eltrombopag to increase the number of platelets in patients, thereby allowing them to receive initiation or maintenance therapy with PEG and RBV. Methods Patients with HCV infection and thrombocytopenia (platelet count

Original language	English
Journal	Gastroenterology
Volume	146
Issue number	2
DOIs	https://doi.org/10.1053/j.gastro.2013.10.012
Publication status	Published - Feb 2014

Keywords

Blood Clot
Complication
Liver Disease
Portal Hypertension

ASJC Scopus subject areas

Gastroenterology

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10.1053/j.gastro.2013.10.012

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Afdhal, N. H., Dusheiko, G. M., Giannini, E. G., Chen, P. J., Han, K. H., Mohsin, A., Rodriguez-Torres, M., Rugina, S., Bakulin, I., Lawitz, E., Shiffman, M. L., Tayyab, G. U. N., Poordad, F., Kamel, Y. M., Brainsky, A., Geib, J., Vasey, S. Y., Patwardhan, R., Campbell, F. M., & Theodore, D. (2014). Eltrombopag increases platelet numbers in thrombocytopenic patients with hcv infection and cirrhosis, allowing for effective antiviral therapy. Gastroenterology, 146(2). https://doi.org/10.1053/j.gastro.2013.10.012

Eltrombopag increases platelet numbers in thrombocytopenic patients with hcv infection and cirrhosis, allowing for effective antiviral therapy. / Afdhal, Nezam H.; Dusheiko, Geoffrey M.; Giannini, Edoardo G.; Chen, Pei Jer; Han, Kwang Hyub; Mohsin, Aftab; Rodriguez-Torres, Maribel; Rugina, Sorin; Bakulin, Igor; Lawitz, Eric; Shiffman, Mitchell L.; Tayyab, Ghias Un Nabi; Poordad, Fred; Kamel, Yasser Mostafa; Brainsky, Andres; Geib, James; Vasey, Sandra Y.; Patwardhan, Rita; Campbell, Fiona M.; Theodore, Dickens.

In: Gastroenterology, Vol. 146, No. 2, 02.2014.

Research output: Contribution to journal › Article › peer-review

Afdhal, NH, Dusheiko, GM, Giannini, EG, Chen, PJ, Han, KH, Mohsin, A, Rodriguez-Torres, M, Rugina, S, Bakulin, I, Lawitz, E, Shiffman, ML, Tayyab, GUN, Poordad, F, Kamel, YM, Brainsky, A, Geib, J, Vasey, SY, Patwardhan, R, Campbell, FM & Theodore, D 2014, 'Eltrombopag increases platelet numbers in thrombocytopenic patients with hcv infection and cirrhosis, allowing for effective antiviral therapy', Gastroenterology, vol. 146, no. 2. https://doi.org/10.1053/j.gastro.2013.10.012

Afdhal, Nezam H. ; Dusheiko, Geoffrey M. ; Giannini, Edoardo G. ; Chen, Pei Jer ; Han, Kwang Hyub ; Mohsin, Aftab ; Rodriguez-Torres, Maribel ; Rugina, Sorin ; Bakulin, Igor ; Lawitz, Eric ; Shiffman, Mitchell L. ; Tayyab, Ghias Un Nabi ; Poordad, Fred ; Kamel, Yasser Mostafa ; Brainsky, Andres ; Geib, James ; Vasey, Sandra Y. ; Patwardhan, Rita ; Campbell, Fiona M. ; Theodore, Dickens. / Eltrombopag increases platelet numbers in thrombocytopenic patients with hcv infection and cirrhosis, allowing for effective antiviral therapy. In: Gastroenterology. 2014 ; Vol. 146, No. 2.

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abstract = "Background & Aims Thrombocytopenia is common among patients with hepatitis C virus (HCV) infection and advanced fibrosis or cirrhosis, limiting initiation and dose of peginterferon-alfa (PEG) and ribavirin (RBV) therapy. The phase 3 randomized, controlled studies, Eltrombopag to Initiate and Maintain Interferon Antiviral Treatment to Benefit Subjects with Hepatitis C-Related Liver Disease (ENABLE)-1 and ENABLE-2, investigated the ability of eltrombopag to increase the number of platelets in patients, thereby allowing them to receive initiation or maintenance therapy with PEG and RBV. Methods Patients with HCV infection and thrombocytopenia (platelet count ",

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AU - Dusheiko, Geoffrey M.

AU - Giannini, Edoardo G.

AU - Chen, Pei Jer

AU - Han, Kwang Hyub

AU - Mohsin, Aftab

AU - Rodriguez-Torres, Maribel

AU - Rugina, Sorin

AU - Bakulin, Igor

AU - Lawitz, Eric

AU - Shiffman, Mitchell L.

AU - Tayyab, Ghias Un Nabi

AU - Poordad, Fred

AU - Kamel, Yasser Mostafa

AU - Brainsky, Andres

AU - Geib, James

AU - Vasey, Sandra Y.

AU - Patwardhan, Rita

AU - Campbell, Fiona M.

AU - Theodore, Dickens

PY - 2014/2

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AB - Background & Aims Thrombocytopenia is common among patients with hepatitis C virus (HCV) infection and advanced fibrosis or cirrhosis, limiting initiation and dose of peginterferon-alfa (PEG) and ribavirin (RBV) therapy. The phase 3 randomized, controlled studies, Eltrombopag to Initiate and Maintain Interferon Antiviral Treatment to Benefit Subjects with Hepatitis C-Related Liver Disease (ENABLE)-1 and ENABLE-2, investigated the ability of eltrombopag to increase the number of platelets in patients, thereby allowing them to receive initiation or maintenance therapy with PEG and RBV. Methods Patients with HCV infection and thrombocytopenia (platelet count

KW - Blood Clot

KW - Complication

KW - Liver Disease

KW - Portal Hypertension

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Eltrombopag increases platelet numbers in thrombocytopenic patients with hcv infection and cirrhosis, allowing for effective antiviral therapy

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Keywords

ASJC Scopus subject areas

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