EMA-biopsy: Un nuovo test per semplificare la diagnosi di celiachia nei casi dubbi e difficili

Translated title of the contribution: EMA-biopsy: A new simple test for the diagnosis of coeliac disease in difficult cases

Michela Pandullo, Luigina De Leo, Alessandro Ventura, Tarcisio Not

Research output: Contribution to journalArticlepeer-review

Abstract

The anti-transglutaminase IgA deposits in the intestinal mucosa, detected by a double-sided direct immunofluorescence (IFD) technique, are the best diagnostic marker for coeliac disease. However, this test is time consuming and largely operator- dependent. This study compared the sensibility and specificity of IgA deposits IFD-test with a new simpler test (EMA-biopsy test), based on the search of the EMA and anti-tTG antibodies in the supernatant of an intestinal mucosa fragment. One hundred thirty-four patients undergoing intestinal biopsy for suspected coeliac disease or for other conditions entered the study. The IFD and EMA-biopsy test showed a comparable, absolute sensibility and specificity for the diagnosis of coeliac disease both in clinically overt cases and in latent ones. EMA-biopsy test may by considered a very useful, simple test for diagnosing or excluding coeliac disease, especially when the clinical, serological and histological picture is not decisive.

Translated title of the contributionEMA-biopsy: A new simple test for the diagnosis of coeliac disease in difficult cases
Original languageItalian
Pages (from-to)528-530
Number of pages3
JournalMedico e Bambino
Volume37
Issue number8
Publication statusPublished - Oct 1 2018

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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