TY - JOUR
T1 - Embryo quality before and after slow freezing
T2 - Viability, implantation and pregnancy rates in 627 single frozen-thawed embryo replacement cycles following failure of fresh transfer
AU - Capodanno, Francesco
AU - De Feo, Gaetano
AU - Gizzo, Salvatore
AU - Nicoli, Alessia
AU - Palomba, Stefano
AU - La Sala, Giovanni Battista
PY - 2016/1/24
Y1 - 2016/1/24
N2 - Frozen embryo transfer cycles are now common practice, however, various aspects regarding the potential of frozen embryos remain unclear. The main goal of the present study was to assess embryo quality before and after slow freezing procedure, and more specifically blastomere loss and embryo quality as indicator of viability. A single center retrospective analysis of single frozen-thawed embryo replacements (s-FER) was performed. The embryo quality before and after slow freezing and thawing, implantation, and pregnancy rates were recorded. One hundred and twenty seven s-FER were included in the final analysis. The probability of achieving an ongoing pregnancy was significantly associated with embryo quality and the percentage of blastomere loss after thawing. Considering thawed embryos, a non-significant difference in term of implantation rate was observed, regardless to their post-thawing quality and the percentage of blastomeres loss. In conclusion, current data suggest that thawed embryos are capable of implantation regardless of their morphological quality and the degree of cryoinjury sustained.
AB - Frozen embryo transfer cycles are now common practice, however, various aspects regarding the potential of frozen embryos remain unclear. The main goal of the present study was to assess embryo quality before and after slow freezing procedure, and more specifically blastomere loss and embryo quality as indicator of viability. A single center retrospective analysis of single frozen-thawed embryo replacements (s-FER) was performed. The embryo quality before and after slow freezing and thawing, implantation, and pregnancy rates were recorded. One hundred and twenty seven s-FER were included in the final analysis. The probability of achieving an ongoing pregnancy was significantly associated with embryo quality and the percentage of blastomere loss after thawing. Considering thawed embryos, a non-significant difference in term of implantation rate was observed, regardless to their post-thawing quality and the percentage of blastomeres loss. In conclusion, current data suggest that thawed embryos are capable of implantation regardless of their morphological quality and the degree of cryoinjury sustained.
KW - ART
KW - Embryos
KW - Freezing
KW - Infertility
KW - Outcome
UR - http://www.scopus.com/inward/record.url?scp=84962703438&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962703438&partnerID=8YFLogxK
U2 - 10.1016/j.repbio.2016.03.002
DO - 10.1016/j.repbio.2016.03.002
M3 - Article
JO - Reproductive biology
JF - Reproductive biology
SN - 1642-431X
ER -